Document Detail

Synthesis and antiproliferative activity of new coumarin-based benzopyranone derivatives against human tumor cell lines.
MedLine Citation:
PMID:  21222615     Owner:  NLM     Status:  MEDLINE    
The synthesis and antiproliferative activity of new coumarin-based benzopyranone derivatives containing basic amino side chain are described. The cytotoxicities against A549 and MCF-7 human cancerous cell lines were determined after 24, 48, 72 h drug exposure employing MTT assay at concentrations ranging from 0-100 μM. The antiproliferative activities of these compounds were compared to tamoxifen (TAM), 4-hydroxytamoxifen (4-OHT), raloxifene (RAL), 17β-estradiol (E2) and Diethylstilbestrol (DES). In vitro results indicated that compounds 10 and 12 were the most potent showing significant inhibitory activities against these cell lines. Furthermore, their antiproliferative activity against MCF-7 human breast cancer cell line is comparable to that of TAM, RAL and 4-OHT.
Musiliyu A Musa; Ailing Zhou; Omowunmi A Sadik
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Medicinal chemistry (Shāriqah (United Arab Emirates))     Volume:  7     ISSN:  1875-6638     ISO Abbreviation:  Med Chem     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2011-08-01     Revised Date:  2012-03-14    
Medline Journal Info:
Nlm Unique ID:  101240303     Medline TA:  Med Chem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  112-20     Citation Subset:  IM    
Department of Chemistry, Florida A & M University, 219 Jones Halls, Tallahassee, FL 32307, USA.
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MeSH Terms
Antineoplastic Agents / chemical synthesis*,  chemistry,  pharmacology*
Cell Line, Tumor
Cell Proliferation / drug effects
Coumarins / chemical synthesis,  chemistry*,  pharmacology*
Inhibitory Concentration 50
Neoplasms / drug therapy,  pathology*
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents; 0/Coumarins

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