Document Detail


Synthesis and anticancer activity of novel betulinic acid and betulin derivatives.
MedLine Citation:
PMID:  20726008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of novel betulinic acid derivatives 3-11 and betulin derivatives 12-17 were synthesized. The compounds were characterized by the means of (1)H- and (13)C-NMR spectroscopy as well as mass spectrometry. The compounds have been tested on ten tumor cell lines of different histogenic origin. The most active derivatives, containing a chloroacetyl group on C-3 in betulinic acid 9 and C-28 in betulin 15, were up to ten times more cytotoxic and many fold more selective towards tumor cells in comparison to normal cells (fibroblasts) than betulinic acid. Furthermore, compound 15 was found to possess cell growth inhibition even when treated for a short time on anaplastic thyroid cancer cells (SW1736).
Authors:
Harish Kommera; Goran N Kaluderović; Jutta Kalbitz; Reinhard Paschke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archiv der Pharmazie     Volume:  343     ISSN:  1521-4184     ISO Abbreviation:  Arch. Pharm. (Weinheim)     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330167     Medline TA:  Arch Pharm (Weinheim)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  449-57     Citation Subset:  IM    
Affiliation:
Biozentrum, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / chemical synthesis*,  pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Drug Screening Assays, Antitumor
Humans
Mass Spectrometry
Structure-Activity Relationship
Thyroid Neoplasms / drug therapy,  pathology
Triterpenes / chemical synthesis*,  pharmacology
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Triterpenes; 472-15-1/betulinic acid; 473-98-3/betulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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