| Synthesis and anticancer activity of novel betulinic acid and betulin derivatives. | |
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MedLine Citation:
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PMID: 20726008 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of novel betulinic acid derivatives 3-11 and betulin derivatives 12-17 were synthesized. The compounds were characterized by the means of (1)H- and (13)C-NMR spectroscopy as well as mass spectrometry. The compounds have been tested on ten tumor cell lines of different histogenic origin. The most active derivatives, containing a chloroacetyl group on C-3 in betulinic acid 9 and C-28 in betulin 15, were up to ten times more cytotoxic and many fold more selective towards tumor cells in comparison to normal cells (fibroblasts) than betulinic acid. Furthermore, compound 15 was found to possess cell growth inhibition even when treated for a short time on anaplastic thyroid cancer cells (SW1736). |
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Authors:
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Harish Kommera; Goran N Kaluderović; Jutta Kalbitz; Reinhard Paschke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archiv der Pharmazie Volume: 343 ISSN: 1521-4184 ISO Abbreviation: Arch. Pharm. (Weinheim) Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0330167 Medline TA: Arch Pharm (Weinheim) Country: Germany |
Other Details:
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Languages: eng Pagination: 449-57 Citation Subset: IM |
Affiliation:
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Biozentrum, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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chemical synthesis*,
pharmacology Cell Line, Tumor Cell Proliferation / drug effects Drug Screening Assays, Antitumor Humans Mass Spectrometry Structure-Activity Relationship Thyroid Neoplasms / drug therapy, pathology Triterpenes / chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Triterpenes; 472-15-1/betulinic acid; 473-98-3/betulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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