| Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature. | |
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MedLine Citation:
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PMID: 20139608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near-ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near-ultraviolet light at 4 degrees C. It indicates that this coupling reaction at 4 degrees C occurs non-enzymatically. |
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Authors:
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Mamiko Asano; Kazuo Harada; Tomoaki Yoshikawa; Takeshi Bamba; Kazumasa Hirata |
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Publication Detail:
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Type: Journal Article Date: 2010-02-07 |
Journal Detail:
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Title: Bioscience, biotechnology, and biochemistry Volume: 74 ISSN: 1347-6947 ISO Abbreviation: Biosci. Biotechnol. Biochem. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-24 Completed Date: 2010-05-20 Revised Date: 2010-05-26 |
Medline Journal Info:
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Nlm Unique ID: 9205717 Medline TA: Biosci Biotechnol Biochem Country: Japan |
Other Details:
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Languages: eng Pagination: 386-9 Citation Subset: IM |
Affiliation:
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Department of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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metabolism* Catharanthus / metabolism*, radiation effects* Cold Temperature Indole Alkaloids / metabolism* Ultraviolet Rays* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Indole Alkaloids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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