Document Detail


Synthesis of Amino Core Compounds of Galactosyl Phytosyl Ceramide Analogs for Developing iNKT-Cell Inducers.
MedLine Citation:
PMID:  22410417     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
1-Aminophytosphingosine and 6-aminogalactosyl phytosphingosine were prepared in 61% and 40% yield libraries with 44 carboxylic acids showed that a 4-butylbenzoic acid-derived product exe, respectively. Glycosylation using benzoyl-protected lipid resulted in better a-selectivity for ceramide analogs, but the yield was less than that obtained with benzyl moieties. Screening the amide rted less cytotoxicity. These analogs were purified for validation of immunological potencies and the a-GalCer analog but not the sphingosine analog stimulated human iNKT cell population.
Authors:
Yin-Cheng Huang; Li-Wu Chiang; Kai-Shiang Chang; Wen-Chin Su; Yi-Hsian Lin; Kee-Ching Jeng; Kun-I Lin; Kuo-Yen Liao; Ho-Lein Huang; Chung-Shan Yu
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Publication Detail:
Type:  Journal Article     Date:  2012-03-12
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  17     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3058-81     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Chang Gung Memorial Hospital and Department of Medicine, Chang Gung University, Taoyuan 33305, Taiwan. csyu@mx.nthu.edu.tw.
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