| Synthesis of AB diblock copolymers by atom-transfer radical polymerization (ATRP) and living polymerization of alpha-amino acid-N-carboxyanhydrides. | |
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MedLine Citation:
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PMID: 15468248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthesis of poly(methyl acrylate)-block-poly(gamma-benzyl-L-glutamate) (PMA-b-PBLG) diblock copolymers, using atom-transfer radical polymerization (ATRP) of methyl acrylate and living polymerization of gamma-benzyl-L-glutamate-N-carboxyanhydride (Glu-NCA) is described. Amido-amidate nickelacycle end groups were incorporated onto amino-terminated poly(methyl acrylates), and the resulting complexes were successfully used as macroinitiators for the growth of polypeptide segments. This method allows the controlled preparation of polypeptide-block-poly(methyl acrylate) diblock architectures with control over polypeptide chain length and without the formation of homopolypeptide contaminants. |
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Authors:
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Krystyna R Brzezinska; Timothy J Deming |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Macromolecular bioscience Volume: 4 ISSN: 1616-5187 ISO Abbreviation: Macromol Biosci Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-10-06 Completed Date: 2005-03-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
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Languages: eng Pagination: 566-9 Citation Subset: IM |
Affiliation:
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Materials Research Laboratory, Chemistry Department, University of California, Santa Barbara, Santa Barbara, California 93106, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Anhydrides / chemistry* Calorimetry, Differential Scanning Polyglutamic Acid / analogs & derivatives*, chemistry* Polymers / chemical synthesis* Polymethacrylic Acids / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Anhydrides; 0/Polymers; 0/Polymethacrylic Acids; 25014-27-1/poly-gamma-benzyl-L-glutamate; 25087-26-7/polymethacrylic acid; 25513-46-6/Polyglutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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