Document Detail


Synthesis of 7-thiaarachidonic acid as a mechanistic probe of prostaglandin H synthase-2.
MedLine Citation:
PMID:  17485208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism by which prostaglandin synthase converts arachidonic acid to prostaglandin G(2), creating five new chiral centers in the process, is still incompletely understood. The first radical intermediate has been characterized by EPR spectroscopy but subsequent proposed intermediates have not succumbed to detection. We report the synthesis of 7-thiaarachidonic acid designed to stabilize one of the proposed radical intermediates, which may allow its detection.
Authors:
Chris M McGinley; Cyril Jacquot; Wilfred A van der Donk
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-27
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  17     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-22     Completed Date:  2007-09-24     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  4049-52     Citation Subset:  IM    
Affiliation:
Roger Adams Laboratory, Department of Chemistry, University of Illinois, 600 S. Mathews Avenue, Urbana, IL 61801, USA.
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MeSH Terms
Descriptor/Qualifier:
Arachidonic Acids / chemical synthesis*
Cyclooxygenase 2 / chemistry*
Electron Spin Resonance Spectroscopy
Molecular Probes*
Grant Support
ID/Acronym/Agency:
GM44911/GM/NIGMS NIH HHS; R01 GM044911-14/GM/NIGMS NIH HHS; R01 GM044911-15/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Molecular Probes; EC 1.14.99.1/Cyclooxygenase 2
Comments/Corrections

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