| Synthesis of 5-alkylated barbituric acids and 3-alkylated indoles via microwave-assisted three-component reactions in solvent-free conditions using Hantzsch 1,4-dihydropyridines as reducing agents. | |
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MedLine Citation:
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PMID: 22297663 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Reaction of barbituric acids with aldehydes and dihydropyridines in one pot under microwave (MW) irradiation in the absence of solvent, affords 55-82% of the 5-benzylated barbituric acids. Use of alkyl nitriles or barbituric acids with indole-3-aldehyde and dihydropyridine (DHP) afforded 3-alkylated indoles in 57-76 % yield. In each case DHPs are converted to pyridines. |
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Authors:
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Biswajita Baruah; P Seetham Naidu; Pallabi Borah; Pulak J Bhuyan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
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Title: Molecular diversity Volume: - ISSN: 1573-501X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516534 Medline TA: Mol Divers Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medicinal Chemistry Division, North East Institute of Science & Technology, Jorhat, 785006, Assam, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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