Document Detail

Synthesis of (3R,4S)-3,4,5-trihydroxy-4-methylpentylphosphonic acid as a potential inhibitor of the nonmevalonate pathway.
MedLine Citation:
PMID:  15215589     Owner:  NLM     Status:  MEDLINE    
The nonmevalonate pathway is widely found in higher plants and in many eubacteria, including pathogenic ones, but not in mammals. Identifying a nonmevalonate pathway inhibitor would greatly contribute to the search for new herbicides and antibacterial drugs to treat, for example, malaria. We describe here the synthesis of (3R,4S)-3,4,5-trihydroxy-4-methylpentylphosphonic acid as a candidate for inhibiting MEP cytidylyltransferase, which is the third step on the nonmevalonate pathway.
Toshiaki Yoshioka; Hiroki Shimizu; Hiroshi Ohrui
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bioscience, biotechnology, and biochemistry     Volume:  68     ISSN:  0916-8451     ISO Abbreviation:  Biosci. Biotechnol. Biochem.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-24     Completed Date:  2005-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205717     Medline TA:  Biosci Biotechnol Biochem     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1259-64     Citation Subset:  IM    
Graduate School of Life Sciences, Tohoku University, Sendai, Miygai, Japan.
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MeSH Terms
Anti-Bacterial Agents / chemical synthesis
Erythritol / analogs & derivatives*,  metabolism*
Escherichia coli / drug effects
Nucleotidyltransferases / antagonists & inhibitors*
Pentanes / chemical synthesis,  pharmacology*
Phosphonic Acids / chemical synthesis*,  pharmacology*
Sugar Phosphates / metabolism*
Reg. No./Substance:
0/(3R,4S)-3,4,5-trihydroxy-4-methylpentylphosphonic acid; 0/2-C-methylerythritol 4-phosphate; 0/Anti-Bacterial Agents; 0/Pentanes; 0/Phosphonic Acids; 0/Sugar Phosphates; 149-32-6/Erythritol; EC 2.7.7.-/2-C-methyl erythritol 4-phosphate cytidylyltransferase; EC 2.7.7.-/Nucleotidyltransferases

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