| Synthesis of 3'- and 6'-functionalized locked nucleic acid (LNA) analogues. | |
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MedLine Citation:
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PMID: 18776290 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Two locked nucleic acid (LNA) analogues, i.e. a 3'-C-hydroxymethyl derivative and a 6'(R)-hydroxymethyl derivative of the LNA thymidine monomer, have been synthesized efficiently using convergent strategies. The hydroxymethyl group at the 3'-position or the 6'-position provides a versatile starting point for various modifications of LNA. |
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Authors:
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Pawan K Sharma; Gerald Enderlin; Surender Kumar; Poul Nielsen |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleic acids symposium series (2004) Volume: - ISSN: 1746-8272 ISO Abbreviation: Nucleic Acids Symp Ser (Oxf) Publication Date: 2008 |
Date Detail:
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Created Date: 2008-09-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101259965 Medline TA: Nucleic Acids Symp Ser (Oxf) Country: England |
Other Details:
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Languages: eng Pagination: 135-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Kurukshetra University, Kurukshetra-136 119, India. talk2pawan@gmail.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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