| Synthesis of 3-(2, 8, 9-Trioxa-5-Aza-1-Germatricyclo [3.3.3.0] Undecane-1-Yl)-3-(4-Hydroxyl-3- Methoxyphenyl)-Propionic Acid and its Inhibitory Effect on the Cervical Tumor U14 In Vitro and In Vivo. | |
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MedLine Citation:
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PMID: 22548339 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study, the novel germatrane compound, 3-(2, 8, 9-trioxa-5-aza-1- germatricyclo [3.3.3.0] undecane-1-yl)-3-(4-hydroxy-3- methoxyphenyl)-propionic acid (1), has been synthesized and its activities against cervical tumor U14 were evaluated in vitro and in vivo. The results have demonstrated that the compound posed significant inhibition on U14 tumor with IC50 values of 48.57 mg/L in cell-based assay and tumor inhibitory rates of 38.50 %, 47.17 % and 64.02 % (from low dose to high dose) in animal experiment. |
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Authors:
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Lianbao Ye; Xiaomin Ou; Xuedong Peng; Yan Luo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-27 |
Journal Detail:
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Title: Medicinal chemistry (Shariqah (United Arab Emirates)) Volume: - ISSN: 1875-6638 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101240303 Medline TA: Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Medicinal Chemistry Department, Guangdong Pharmaceutical University, Guangzhou, Guangdong, 510006, China. ywpl110@163.com; yelb7909@163.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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