| Synthesis of 2'-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells. | |
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MedLine Citation:
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PMID: 17113288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2'-paclitaxel and methyl 2'-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy. |
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Authors:
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Der-Zen Liu; Supachok Sinchaikul; Peddiahgari Vasu Govardhana Reddy; Meng-Yang Chang; Shui-Tein Chen |
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Publication Detail:
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Type: Journal Article Date: 2006-11-07 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 17 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-01-22 Completed Date: 2007-04-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 617-20 Citation Subset: IM |
Affiliation:
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Graduate Institute of Biomedical Materials, Taipei Medical University, Taipei 110, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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chemical synthesis*,
pharmacology* Cell Line, Tumor Cell Membrane / drug effects, metabolism Chemistry, Physical Chromatography, High Pressure Liquid Glucose Transport Proteins, Facilitative / metabolism Humans Indicators and Reagents Neoplasms / drug therapy*, pathology Paclitaxel / analogs & derivatives*, chemical synthesis*, pharmacology Physicochemical Phenomena Solubility Succinates / chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/2'-paclitaxel methyl 2-glucopyranosyl succinate; 0/Antineoplastic Agents, Phytogenic; 0/Glucose Transport Proteins, Facilitative; 0/Indicators and Reagents; 0/Succinates; 33069-62-4/Paclitaxel |
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