Document Detail


Synthesis of 2'-paclitaxel methyl 2-glucopyranosyl succinate for specific targeted delivery to cancer cells.
MedLine Citation:
PMID:  17113288     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2'-paclitaxel and methyl 2'-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.
Authors:
Der-Zen Liu; Supachok Sinchaikul; Peddiahgari Vasu Govardhana Reddy; Meng-Yang Chang; Shui-Tein Chen
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Publication Detail:
Type:  Journal Article     Date:  2006-11-07
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  17     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-22     Completed Date:  2007-04-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  617-20     Citation Subset:  IM    
Affiliation:
Graduate Institute of Biomedical Materials, Taipei Medical University, Taipei 110, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents, Phytogenic / chemical synthesis*,  pharmacology*
Cell Line, Tumor
Cell Membrane / drug effects,  metabolism
Chemistry, Physical
Chromatography, High Pressure Liquid
Glucose Transport Proteins, Facilitative / metabolism
Humans
Indicators and Reagents
Neoplasms / drug therapy*,  pathology
Paclitaxel / analogs & derivatives*,  chemical synthesis*,  pharmacology
Physicochemical Phenomena
Solubility
Succinates / chemical synthesis*,  pharmacology
Chemical
Reg. No./Substance:
0/2'-paclitaxel methyl 2-glucopyranosyl succinate; 0/Antineoplastic Agents, Phytogenic; 0/Glucose Transport Proteins, Facilitative; 0/Indicators and Reagents; 0/Succinates; 33069-62-4/Paclitaxel

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