| Synthesis of 2-oxoamides based on sulfonamide analogs of gamma-amino acids and their activity on phospholipase A2. | |
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MedLine Citation:
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PMID: 18618424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A variety of lipophilic 2-oxoamides containing sulfonamide analogs of gamma-amino acids as well as acyl sulfonamides of gamma-aminobutyric acid were synthesized. Their ability to inhibit intracellular GIVA cPLA2 and GVIA iPLA2 as well as secreted GV sPLA2 was evaluated. The sulfonamide group seems a bioisosteric group suitable to replace the carboxyl group in 2-oxoamide inhibitors of GVIA cPLA2. |
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Authors:
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Georgia Antonopoulou; Victoria Magrioti; Daren Stephens; Violetta Constantinou-Kokotou; Edward A Dennis; George Kokotos |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of peptide science : an official publication of the European Peptide Society Volume: 14 ISSN: 1075-2617 ISO Abbreviation: J. Pept. Sci. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-30 Completed Date: 2008-11-25 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 9506309 Medline TA: J Pept Sci Country: England |
Other Details:
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Languages: eng Pagination: 1111-20 Citation Subset: IM |
Copyright Information:
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Copyright 2008 European Peptide Society and John Wiley & Sons, Ltd. |
Affiliation:
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Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry*,
physiology* Humans Isoenzymes / antagonists & inhibitors, metabolism Phospholipases A2 / antagonists & inhibitors, metabolism* Pyridines / chemical synthesis*, pharmacology Sulfonamides / chemistry*, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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GM 20,501/GM/NIGMS NIH HHS; R01 GM020501-32/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Isoenzymes; 0/Pyridines; 0/Sulfonamides; 713-05-3/oxoamide; EC 3.1.1.4/Phospholipases A2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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