| Synthesis of 2'-fluoro-5-[11C]-methyl-1-beta-D-arabinofuranosyluracil ([11C]-FMAU): a potential nucleoside analog for in vivo study of cellular proliferation with PET. | |
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MedLine Citation:
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PMID: 8535339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rapid in vivo catabolism limits the use of currently available radiotracers used in tumor proliferation studies with PET. This is manifested by the need to develop complex mathematical models to interpret kinetic and metabolite data obtained from imaging studies with agents such as carbon-11 labeled thymidine. A potential carbon-11 labeled radiotracer for cellular proliferation, 2'-fluoro-5-([11C]-methyl)-1-beta-D-arabinofuranosyluracil (FMAU), has been prepared using a previously described method for preparation of [11C]methyl-thymidine where selective alkylation of a pyrimidyl dianion is accomplished with [11C]methyl iodide at the 5-position of the pyrimidine ring. FMAU shares many in vivo characteristics of thymidine, including cellular transport, phosphorylation by mammalian kinase, and incorporation into DNA. Most importantly, in vivo catabolism of FMAU is limited, potentially yielding simplified kinetic models for determination of cellular proliferation with positron emission tomography. |
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Authors:
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P S Conti; M M Alauddin; J R Fissekis; B Schmall; K A Watanabe |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nuclear medicine and biology Volume: 22 ISSN: 0969-8051 ISO Abbreviation: Nucl. Med. Biol. Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1996-02-08 Completed Date: 1996-02-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9304420 Medline TA: Nucl Med Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 783-9 Citation Subset: IM |
Affiliation:
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PET Imaging Science Center, University of Southern California, School of Medicine, Los Angeles, CA 90033, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arabinofuranosyluracil / analogs & derivatives*, chemical synthesis, diagnostic use Carbon Radioisotopes* Cell Division Humans Indicators and Reagents Isotope Labeling / methods Kinetics Models, Theoretical* Tomography, Emission-Computed* |
| Grant Support | |
ID/Acronym/Agency:
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CA-09022/CA/NCI NIH HHS; CA-18153/CA/NCI NIH HHS; CA-37870/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carbon Radioisotopes; 0/Indicators and Reagents; 3083-77-0/Arabinofuranosyluracil; 69256-17-3/2'-fluoro-5-methylarabinosyluracil |
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