Document Detail

Synthesis of 2-azaspiro[3.3]heptane-derived amino acids: ornitine and GABA analogues.
MedLine Citation:
PMID:  20108009     Owner:  NLM     Status:  MEDLINE    
Synthesis of 6-amino-2-azaspiro[3.3]heptane-6-carboxylic acid and 2-azaspiro[3.3]heptane-6-carboxylic acid was performed. Both four-membered rings in the spirocyclic scaffold were constructed by subsequent ring closure of corresponding 1,3-bis-electrophiles at 1,1-C- or 1,1-N-bis-nucleophiles. The two novel amino acids were added to the family of the sterically constrained amino acids for the use in chemistry, biochemistry, and drug design.
Dmytro S Radchenko; Oleksandr O Grygorenko; Igor V Komarov
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Publication Detail:
Type:  Journal Article     Date:  2010-01-27
Journal Detail:
Title:  Amino acids     Volume:  39     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-25     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  515-21     Citation Subset:  IM    
Enamine Ltd., Aleksandra Matrosova Street, 23, Kyiv, 01103, Ukraine.
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MeSH Terms
Aza Compounds / chemical synthesis*
Ornithine / analogs & derivatives*,  chemical synthesis
Spiro Compounds / chemical synthesis*
gamma-Aminobutyric Acid / analogs & derivatives*,  chemical synthesis
Reg. No./Substance:
0/Aza Compounds; 0/Spiro Compounds; 56-12-2/gamma-Aminobutyric Acid; 7006-33-9/Ornithine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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