Document Detail


Synthesis of 2-(allylthio)pyrazines as a novel cancer chemopreventive agent.
MedLine Citation:
PMID:  11235806     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
2-(Allylthio)pyrazine derivatives were designed as a novel cancer chemopreventive agent that functions through selective inhibtion of cytochrome P-450 and induction of phase II enzymes involved in the detoxification of carcinogens. A practical preparation method of 2-(allylthio) pyrazine derivatives was established by the reaction of 2-mercaptopyrazine and allylbromides in the presence of a catalytic antioxidant, DABCO (1,4-diazabicyclo[2,2,2] octane), in dimethylformamide at below 50 degrees C.
Authors:
J W Lee; B Lee; N D Kim
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of pharmacal research     Volume:  24     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-08     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Affiliation:
Yuan Research Center, Kyonggi-Do, Korea. leejw@yuhan.co.kr
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MeSH Terms
Descriptor/Qualifier:
Anticarcinogenic Agents / chemical synthesis*,  therapeutic use
Enzyme Inhibitors / chemical synthesis*,  therapeutic use
Neoplasms / drug therapy,  prevention & control
Pyrazines / chemical synthesis*,  therapeutic use
Chemical
Reg. No./Substance:
0/2-(allylthio)pyrazine; 0/Anticarcinogenic Agents; 0/Enzyme Inhibitors; 0/Pyrazines

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