| Synthesis of 1,2,4-triazole derivatives: binding properties on endothelin receptors. | |
| | |
MedLine Citation:
|
PMID: 18045205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In the present study we describe the synthesis of a new series of 1,2,4-triazoles: [3-(arylmethyl)thio-5-aryl-4H-[1,2,4]triazol-4-yl]acetic acids 5a-g, [5-(arylmethyl)thio-3-aryl-1H-[1,2,4]triazol-1-yl]acetic acids 8a-d, and [3-(aryl-methyl)thio-5-aryl-1H-[1,2,4]triazol-1-yl] acetic acids 9a-d. These compounds were tested in binding assays to evaluate their ability as ligands for human ET(A) and ET(B) receptors stably expressed in CHO cells; some of the tested compounds showed affinity in the micromolar range. |
| | |
Authors:
|
L Salerno; F Guerrera; M Modica; G Romeo; V Pittalà; M A Siracusa; I Mereghetti; A Cagnotto; T Mennini |
Related Documents
:
|
15995855 - White biotechnology for green chemistry: fermentative 2-oxocarboxylic acids as novel bu... 17622565 - Modeling of yeast brettanomyces bruxellensis growth at different acetic acid concentrat... 2113915 - Hyperthermus butylicus, a hyperthermophilic sulfur-reducing archaebacterium that fermen... 16347015 - Growth and metabolism of lactic acid bacteria during and after malolactic fermentation ... 21784025 - Protective effects of eucommia ulmoides oliv. bark and leaf on amyloid β-induced cytot... 447025 - Structure of bile acids associated with secretion in the rat cecum. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Medicinal chemistry (Shāriqah (United Arab Emirates)) Volume: 3 ISSN: 1573-4064 ISO Abbreviation: - Publication Date: 2007 Nov |
Date Detail:
|
Created Date: 2007-11-29 Completed Date: 2007-12-19 Revised Date: 2008-02-26 |
Medline Journal Info:
|
Nlm Unique ID: 101240303 Medline TA: Med Chem Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 551-60 Citation Subset: IM |
Affiliation:
|
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Catania, viale A. Doria, 6, 95125 Catania, Italy. l.salerno@unict.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals CHO Cells Cricetinae Cricetulus Humans Ligands Protein Binding Receptor, Endothelin A / genetics, metabolism Receptor, Endothelin B / genetics, metabolism Receptors, Endothelin / genetics, metabolism* Structure-Activity Relationship Transfection Triazoles / chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Ligands; 0/Receptor, Endothelin A; 0/Receptor, Endothelin B; 0/Receptors, Endothelin; 0/Triazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20a...
Next Document: Design and synthesis of new N-OMe fluoro-indole melatoninergics.