Document Detail

Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors.
MedLine Citation:
PMID:  15109640     Owner:  NLM     Status:  MEDLINE    
Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors.
Hyun-Suk Lim; Jeong-Ju Park; Kwangseok Ko; Mee-Hyun Lee; Sung-Kee Chung
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  14     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-27     Completed Date:  2004-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  2499-503     Citation Subset:  IM    
Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja-Dong, Nam-gu, Pohang 790-784, South Korea.
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MeSH Terms
Binding Sites
Cell Line
Lysophospholipids / chemistry*
Models, Molecular
Protein Binding
Radioligand Assay
Receptors, Lysosphingolipid / chemistry*
Sphingosine / analogs & derivatives*,  chemistry*
Structural Homology, Protein
Structure-Activity Relationship
Reg. No./Substance:
0/Ligands; 0/Lysophospholipids; 0/Receptors, Lysosphingolipid; 123-78-4/Sphingosine; 26993-30-6/sphingosine 1-phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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