| Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. | |
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MedLine Citation:
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PMID: 15109640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sphingosine-1-phosphate (S1P) is an important regulator of a wide variety of biological processes acting as an endogenous ligand to EDG/S1P receptors. In an effort to establish structure-activity relationship between EDG/S1P and ligands, we report herein homology modeling study of EDG-1/S1P(1), syntheses of S1P analogues, and cell based binding affinity study for EDG/S1P receptors. |
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Authors:
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Hyun-Suk Lim; Jeong-Ju Park; Kwangseok Ko; Mee-Hyun Lee; Sung-Kee Chung |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 14 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-04-27 Completed Date: 2004-12-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 2499-503 Citation Subset: IM |
Affiliation:
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Division of Molecular and Life Sciences, Pohang University of Science and Technology, San31, Hyoja-Dong, Nam-gu, Pohang 790-784, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Binding Sites Cell Line Humans Ligands Lysophospholipids / chemistry* Models, Molecular Protein Binding Radioligand Assay Receptors, Lysosphingolipid / chemistry* Sphingosine / analogs & derivatives*, chemistry* Structural Homology, Protein Structure-Activity Relationship Transfection |
| Chemical | |
Reg. No./Substance:
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0/Ligands; 0/Lysophospholipids; 0/Receptors, Lysosphingolipid; 123-78-4/Sphingosine; 26993-30-6/sphingosine 1-phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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