Document Detail


Syntheses and effect of bombesin-fragment6-14 and its four analogues on food intake in rats.
MedLine Citation:
PMID:  11480423     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2, corresponding to amino acids 6 to 14 of bombesin and its four analogues were synthesized by a solid-phase method and were tested for their comparative effect on reducing activity on food intake using male Wistar rats. The synthetic bombesin-fragment6-14 showed reducing effect on food intake using male Wistar rats. Of the synthetic analogues, [Phe(4F)13]bombesin-fragment6-14 exhibited the most potent effect. The reducing effect on food intake of [Sar11]bombesin-fragment6-14 was lower than that of our synthetic bombesin-fragment6-14, but the other two analogues, [betaAla11]bombesin-fragment6-14 and [1-Nal8]bombesin-fragment6-14 showed no reducing effect on food intake in rats.
Authors:
T Abiko; Y Kimura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current pharmaceutical biotechnology     Volume:  2     ISSN:  1389-2010     ISO Abbreviation:  Curr Pharm Biotechnol     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-08-01     Completed Date:  2001-10-04     Revised Date:  2008-05-12    
Medline Journal Info:
Nlm Unique ID:  100960530     Medline TA:  Curr Pharm Biotechnol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  201-7     Citation Subset:  IM    
Affiliation:
Research Laboratory, Global Shinwa Pharmaceutical Co., Ltd., Japan. lab@mx2.alpha-web.ne.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Bombesin / analogs & derivatives,  chemical synthesis*,  pharmacology*
Eating / drug effects*
Male
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
31362-50-2/Bombesin

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