Document Detail


Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.
MedLine Citation:
PMID:  18642835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.
Authors:
Simon Giroux; Axel Bethke; Nicole Fielenbach; Adam Antebi; E J Corey
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-07-19
Journal Detail:
Title:  Organic letters     Volume:  10     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-08     Completed Date:  2008-10-20     Revised Date:  2013-04-12    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3643-5     Citation Subset:  IM    
Affiliation:
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Caenorhabditis elegans / genetics
Caenorhabditis elegans Proteins / chemistry,  drug effects*,  genetics
Ergosterol / analogs & derivatives*,  chemical synthesis,  chemistry,  pharmacology
Ligands
Molecular Conformation
Receptors, Cytoplasmic and Nuclear / chemistry,  drug effects*,  genetics
Stereoisomerism
Transcription, Genetic / drug effects,  genetics
Grant Support
ID/Acronym/Agency:
R01 AG027498-03/AG/NIA NIH HHS; R01 GM077201-03/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/DAF-12 protein, C elegans; 0/Ligands; 0/Receptors, Cytoplasmic and Nuclear; 0/dafachronic acid A; 57-87-4/Ergosterol
Comments/Corrections

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