Document Detail

Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A.
MedLine Citation:
PMID:  18642835     Owner:  NLM     Status:  MEDLINE    
Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.
Simon Giroux; Axel Bethke; Nicole Fielenbach; Adam Antebi; E J Corey
Related Documents :
403285 - Beta-lactam antibiotics derived from nitrogen heterocyclic acetic acids. 1. penicillin ...
23186025 - Self-immolative aryl phthalate esters.
12102185 - Surface engineering of poly(dl-lactic acid) by entrapment of alginate-amino acid deriva...
20876955 - Fabrication, structure and biological properties of organic acid-derived sol-gel bioact...
393605 - Isolation of acidic acrosin isoinhibitors (busi i a, busi ib1 and busi i b2) from bull ...
8609415 - Metabolism of gammalinolenic acid in human neutrophils.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-07-19
Journal Detail:
Title:  Organic letters     Volume:  10     ISSN:  1523-7052     ISO Abbreviation:  Org. Lett.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-08     Completed Date:  2008-10-20     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3643-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Caenorhabditis elegans / genetics
Caenorhabditis elegans Proteins / chemistry,  drug effects*,  genetics
Ergosterol / analogs & derivatives*,  chemical synthesis,  chemistry,  pharmacology
Molecular Conformation
Receptors, Cytoplasmic and Nuclear / chemistry,  drug effects*,  genetics
Transcription, Genetic / drug effects,  genetics
Grant Support
R01 AG027498/AG/NIA NIH HHS; R01 AG027498-03/AG/NIA NIH HHS; R01 GM077201/GM/NIGMS NIH HHS; R01 GM077201-03/GM/NIGMS NIH HHS
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/DAF-12 protein, C elegans; 0/Ligands; 0/Receptors, Cytoplasmic and Nuclear; 0/dafachronic acid A; Z30RAY509F/Ergosterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade re...
Next Document:  Proteomic study of biocontrol mechanisms of Trichoderma harzianum ETS 323 in response to Rhizoctonia...