| Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A. | |
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MedLine Citation:
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PMID: 18642835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans. |
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Authors:
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Simon Giroux; Axel Bethke; Nicole Fielenbach; Adam Antebi; E J Corey |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-07-19 |
Journal Detail:
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Title: Organic letters Volume: 10 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-08 Completed Date: 2008-10-20 Revised Date: 2013-04-12 |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 3643-5 Citation Subset: IM |
Affiliation:
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Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / genetics Caenorhabditis elegans Proteins / chemistry, drug effects*, genetics Ergosterol / analogs & derivatives*, chemical synthesis, chemistry, pharmacology Ligands Molecular Conformation Receptors, Cytoplasmic and Nuclear / chemistry, drug effects*, genetics Stereoisomerism Transcription, Genetic / drug effects, genetics |
| Grant Support | |
ID/Acronym/Agency:
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R01 AG027498-03/AG/NIA NIH HHS; R01 GM077201-03/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/DAF-12 protein, C elegans; 0/Ligands; 0/Receptors, Cytoplasmic and Nuclear; 0/dafachronic acid A; 57-87-4/Ergosterol |
| Comments/Corrections | |
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