Document Detail

Syntactic language processing: ERP lesion data on the role of the basal ganglia.
MedLine Citation:
PMID:  14738286     Owner:  NLM     Status:  MEDLINE    
The role of the basal ganglia in syntactic language processing was investigated with event-related brain potentials in fourteen neurologically impaired patients. Seven of these patients had basal ganglia lesions while 7 other patients primarily had lesions of the left temporo-parietal region excluding the basal ganglia. All patients listened to sentences that were either correct or included a verb argument structure violation. In previous experiments this type of violation elicited a biphasic pattern of an N400-P600 complex in young healthy participants. While the N400 may result from incorrect semantic-thematic role assignment, the P600 reflects the fact that verb information does not license the syntactic structure at present. Results of the patient experiment revealed a double dissociation: patients with left temporo-parietal lesions only show a P600, whereas patients with lesions of the basal ganglia showed no P600, but a negativity with extended duration that resembled an N400. The latter pattern not only confirms previous reports that the basal ganglia modulate the P600 but extends these results by showing that the N400 as a late semantic-thematic integration process appears partially modulated by the basal ganglia.
Sonja A Kotz; Stefan Frisch; D Yves von Cramon; Angela D Friederici
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the International Neuropsychological Society : JINS     Volume:  9     ISSN:  1355-6177     ISO Abbreviation:  J Int Neuropsychol Soc     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-02-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9503760     Medline TA:  J Int Neuropsychol Soc     Country:  England    
Other Details:
Languages:  eng     Pagination:  1053-60     Citation Subset:  IM    
Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany.
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MeSH Terms
Analysis of Variance
Basal Ganglia / physiopathology*
Brain Injuries / classification,  physiopathology*
Brain Mapping
Evoked Potentials / physiology*
Magnetic Resonance Imaging
Middle Aged
Neuropsychological Tests

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