Document Detail

Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy.
MedLine Citation:
PMID:  8150815     Owner:  NLM     Status:  MEDLINE    
Between 1977 and 1992, we performed ninety-two synoviortheses (destruction of synovial tissue by intra-articular injection of a radioactive agent) on forty-eight patients who had a severe congenital disorder of hemostasis and chronic hemophilic synovitis that was resistant to conventional treatment. Colloidal 32P chromic phosphate was injected intra-articularly: 1.0 millicurie for knees and 0.5 millicurie for other joints. The duration of follow-up ranged from one to fifteen years. The frequency and importance of bleeding decreased in most of the patients. The range of motion of half of the joints remained stable or improved and that of the other half continued to decrease. Radiographic scores worsened progressively despite the decreased frequency of hemarthrosis. In most patients, the extra-articular leakage of the radioactive agent was slight. Chromosome breakages were observed almost exclusively in patients who were seropositive for human immunodeficiency virus and in whom the CD4-lymphocyte count was decreased from normal. The patients' level of satisfaction with the results was high.
G E Rivard; M Girard; R Bélanger; M Jutras; J P Guay; D Marton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. American volume     Volume:  76     ISSN:  0021-9355     ISO Abbreviation:  J Bone Joint Surg Am     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-12     Completed Date:  1994-05-12     Revised Date:  2010-10-25    
Medline Journal Info:
Nlm Unique ID:  0014030     Medline TA:  J Bone Joint Surg Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  482-8     Citation Subset:  AIM; IM; X    
Department of Pediatrics, Hôpital Sainte-Justine, Montréal, Québec, Canada.
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MeSH Terms
Chromium Compounds / administration & dosage
Chromosomes, Human / radiation effects
Hemarthrosis / radiotherapy*
Injections, Intra-Articular
Joints / physiology
Phosphates / administration & dosage
Phosphorus Radioisotopes / administration & dosage,  therapeutic use*
Prospective Studies
Range of Motion, Articular
Synovial Membrane / radiation effects*
Reg. No./Substance:
0/Chromium Compounds; 0/Colloids; 0/Phosphates; 0/Phosphorus Radioisotopes; 7789-04-0/chromic phosphate
Comment In:
J Bone Joint Surg Am. 1995 May;77(5):807-8   [PMID:  7744908 ]

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