| Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. | |
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MedLine Citation:
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PMID: 8150815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1977 and 1992, we performed ninety-two synoviortheses (destruction of synovial tissue by intra-articular injection of a radioactive agent) on forty-eight patients who had a severe congenital disorder of hemostasis and chronic hemophilic synovitis that was resistant to conventional treatment. Colloidal 32P chromic phosphate was injected intra-articularly: 1.0 millicurie for knees and 0.5 millicurie for other joints. The duration of follow-up ranged from one to fifteen years. The frequency and importance of bleeding decreased in most of the patients. The range of motion of half of the joints remained stable or improved and that of the other half continued to decrease. Radiographic scores worsened progressively despite the decreased frequency of hemarthrosis. In most patients, the extra-articular leakage of the radioactive agent was slight. Chromosome breakages were observed almost exclusively in patients who were seropositive for human immunodeficiency virus and in whom the CD4-lymphocyte count was decreased from normal. The patients' level of satisfaction with the results was high. |
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Authors:
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G E Rivard; M Girard; R Bélanger; M Jutras; J P Guay; D Marton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of bone and joint surgery. American volume Volume: 76 ISSN: 0021-9355 ISO Abbreviation: J Bone Joint Surg Am Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-05-12 Completed Date: 1994-05-12 Revised Date: 2010-10-25 |
Medline Journal Info:
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Nlm Unique ID: 0014030 Medline TA: J Bone Joint Surg Am Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 482-8 Citation Subset: AIM; IM; X |
Affiliation:
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Department of Pediatrics, Hôpital Sainte-Justine, Montréal, Québec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Chromium Compounds / administration & dosage Chromosomes, Human / radiation effects Colloids Hemarthrosis / radiotherapy* Humans Injections, Intra-Articular Joints / physiology Male Phosphates / administration & dosage Phosphorus Radioisotopes / administration & dosage, therapeutic use* Prospective Studies Range of Motion, Articular Synovial Membrane / radiation effects* |
| Chemical | |
Reg. No./Substance:
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0/Chromium Compounds; 0/Colloids; 0/Phosphates; 0/Phosphorus Radioisotopes; 7789-04-0/chromic phosphate |
| Comments/Corrections | |
Comment In:
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J Bone Joint Surg Am. 1995 May;77(5):807-8
[PMID:
7744908
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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