Document Detail


Synovial sarcoma of the extremities: prognostic factors for 20 nonmetastatic cases and a new histologic grading system with prognostic significance.
MedLine Citation:
PMID:  17072434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate 20 cases of nonmetastatic synovial sarcoma of the extremities regarding prognostic factors, and to propose a histologic grading system with prognostic significance. METHODS: The cases of 20 patients (14 females and 6 males) with nonmetastatic synovial sarcomas of the extremities treated between 1985 and 1998, were retrospectively evaluated regarding prognostic factors. A histologic grading system with prognostic significance is proposed. RESULTS: The mean follow-up period was 48.4 months (range, 16-116 months). There was local recurrence in 3 cases (15%), microscopic surgical margin being the only prognostic factor identified. Seven patients (35%) died of the disease in a mean postoperative period of 31.7 months (range, 16-53 months), all with pulmonary or brain metastasis. The survival rate was 65% in 48.4 months of follow-up. CONCLUSION: The unfavorable prognostic factors identified regarding survival were high histologic grade, tumors proximal to the knee or elbow, and spontaneous tumor necrosis over 25%. Local recurrence did not have influence on survival in this study. The presence of mast cells appears to have a positive influence on survival, although statistical significance was not reached (P = 0.07). The oncologic and functional result was good in 6 cases (30%), regular in 7 (35%), and poor in 7 cases (35%).
Authors:
André Mathias Baptista; Olavo Pires de Camargo; Alberto Tesconi Croci; Cláudia Regina G C M de Oliveira; Raymundo Soares de Azevedo Neto; Marcelo Abrantes Giannotti; Marcelo Tadeu Caiero; Telma Murias dos Santos; Márcia Datz Abadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  61     ISSN:  1807-5932     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-30     Completed Date:  2007-08-16     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  381-6     Citation Subset:  IM    
Affiliation:
Orthopedic Oncology Group, Department of Orthopedics, Hospital das Clínicas, São Paulo University Medical School, São Paulo, SP, Brazil. andre.baptista@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Child
Extremities / pathology*
Female
Humans
Kaplan-Meiers Estimate
Male
Middle Aged
Mitotic Index
Necrosis
Neoplasm Recurrence, Local / classification,  mortality,  pathology
Prognosis
Retrospective Studies
Sarcoma / classification,  mortality,  pathology*
Sarcoma, Synovial / classification,  mortality,  pathology
Sex Distribution
Soft Tissue Neoplasms / classification,  mortality,  pathology*

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