| Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms. | |
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MedLine Citation:
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PMID: 21279996 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Traumatic and degenerative meniscal tears have different anatomic features and different proposed etiologies, yet both are associated with the development or progression of osteoarthritis (OA). In established OA, synovitis is associated with pain and progression, but a relationship between synovitis and symptoms in isolated meniscal disease has not been reported. Accordingly, we sought to characterize synovial pathology in patients with traumatic meniscal injuries and determine the relationships between inflammation, meniscal and cartilage pathology, and symptoms. METHODS: Thirty-three patients without evidence of OA who were undergoing arthroscopic meniscectomy for meniscal injuries were recruited. Pain and function were assessed preoperatively; meniscal and cartilage abnormalities were documented at the time of surgery. Inflammation in synovial biopsy specimens was scored, and associations between inflammation and clinical outcomes were determined. Microarray analysis of synovial tissue was performed, and gene expression patterns in patients with and those without inflammation were compared. RESULTS: Synovial inflammation was present in 43% of the patients and was associated with worse preoperative pain and function scores, independent of age, sex, or cartilage pathology. Microarray analysis and real-time polymerase chain reaction revealed a chemokine signature in synovial biopsy specimens with increased inflammation scores. CONCLUSION: Our findings indicate that in patients with traumatic meniscal injury undergoing arthroscopic meniscectomy without radiographic evidence of OA, synovial inflammation occurs frequently and is associated with increased pain and dysfunction. Synovia with increased inflammation scores exhibit a unique chemokine signature. Chemokines may contribute to the development of synovial inflammation in patients with meniscal pathology; they also represent potential therapeutic targets for reducing inflammatory symptoms. |
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Authors:
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Carla R Scanzello; Brian McKeon; Bryan H Swaim; Edward DiCarlo; Eva U Asomugha; Veero Kanda; Anjali Nair; David M Lee; John C Richmond; Jeffrey N Katz; Mary K Crow; Steven R Goldring |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Arthritis and rheumatism Volume: 63 ISSN: 1529-0131 ISO Abbreviation: Arthritis Rheum. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-03-08 Revised Date: 2013-05-09 |
Medline Journal Info:
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Nlm Unique ID: 0370605 Medline TA: Arthritis Rheum Country: United States |
Other Details:
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Languages: eng Pagination: 391-400 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 by the American College of Rheumatology. |
Affiliation:
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Rush University Medical Center, Section of Rheumatology, Chicago, Illinois 60612, USA. Carla_Scanzello@rush.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Arthroscopy / methods* Cartilage, Articular / pathology, surgery Chemokines / genetics, metabolism Disability Evaluation Female Gene Expression Health Status Humans Knee Joint / metabolism, pathology, physiopathology Male Massachusetts / epidemiology Menisci, Tibial / injuries, pathology*, surgery Middle Aged Osteoarthritis, Knee / metabolism, pathology* Pain / pathology, physiopathology RNA, Messenger / metabolism Synovitis / epidemiology, metabolism, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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K24 AR002123-10/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/RNA, Messenger |
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