| Synopsis of partial-body radiation diagnostic biomarkers and medical management of radiation injury workshop. | |
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MedLine Citation:
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PMID: 20095857 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Radiation exposures from accidents, nuclear detonations or terrorist incidents are unlikely to be homogeneous; however, current biodosimetric approaches are developed and validated primarily in whole-body irradiation models. A workshop was held at the Armed Forces Radiobiology Research Institute in May 2008 to draw attention to the need for partial-body biodosimetry, to discuss current knowledge, and to identify the gaps to be filled. A panel of international experts and the workshop attendees discussed the requirements and concepts for a path forward. This report addresses eight key areas identified by the Workshop Program Committee for future focus: (1) improved cytogenetics, (2) clinical signs and symptoms, (3) cutaneous bioindicators, (4) organ-specific biomarkers, (5) biophysical markers of dose, (6) integrated diagnostic approaches, (7) confounding factors, and (8) requirements for post-event medical follow-up. For each area, the status, advantages and limitations of existing approaches and suggestions for new directions are presented. |
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Authors:
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Pataje G S Prasanna; William F Blakely; Jean-Marc Bertho; John P Chute; Eric P Cohen; Ronald E Goans; Marcy B Grace; Patricia K Lillis-Hearne; David C Lloyd; Ludy C H W Lutgens; Viktor Meineke; Natalia I Ossetrova; Alexander Romanyukha; Julie D Saba; Daniel J Weisdorf; Andrzej Wojcik; Eduardo G Yukihara; Terry C Pellmar |
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Publication Detail:
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Type: Congresses; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Radiation research Volume: 173 ISSN: 1938-5404 ISO Abbreviation: Radiat. Res. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: United States |
Other Details:
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Languages: eng Pagination: 245-53 Citation Subset: IM; S |
Affiliation:
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Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20889, USA. patajeprasanna@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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analysis* Humans Radiation Injuries / diagnosis*, genetics, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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1U19AI067734/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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