Document Detail

Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis.
MedLine Citation:
PMID:  15852403     Owner:  NLM     Status:  MEDLINE    
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the neuromuscular system resulting in paralysis and ultimately death. Currently, no effective therapy is prescribed for patients; however, several therapeutic strategies are showing promise. Either exercise or treatment with adeno-associated virus/insulin-like growth factor-1 alone has therapeutic benefits in an amyotrophic lateral sclerosis transgenic mouse model. We show here that activity duration affects the therapeutic benefit associated with exercise, with 6- and 12-hour exposure to a running wheel providing significant motor function benefits and increased survival. Remarkably, a combination of insulin-like growth factor-1 gene delivery and exercise has profound effects on survival and function, indicative of synergistic effects with exercise and insulin-like growth factor-1. Our results indicate that a drug treatment in combination with appropriate exercise may provide the most promising therapy for amyotrophic lateral sclerosis to date.
Brian K Kaspar; Lindsay M Frost; Lindsey Christian; Priya Umapathi; Fred H Gage
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  57     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-06-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649-55     Citation Subset:  IM    
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
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MeSH Terms
Aging / physiology
Amyotrophic Lateral Sclerosis / drug therapy,  pathology,  therapy*
Brain Chemistry / genetics
Cell Count
Dependovirus / genetics
Exercise Therapy*
Gene Expression
Gene Therapy*
Insulin-Like Growth Factor I / genetics*
Mice, Transgenic
Motor Activity / physiology
Plasmids / genetics
Postural Balance / physiology
RNA / biosynthesis,  genetics
Spinal Cord / pathology
Superoxide Dismutase / genetics
Survival Analysis
Grant Support
Reg. No./Substance:
63231-63-0/RNA; 67763-96-6/Insulin-Like Growth Factor I; EC 1.15.1.-/superoxide dismutase 1; EC Dismutase

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