Document Detail


Synergy of imipenem--a novel carbapenem, and rifampin and ciprofloxacin against Pseudomonas aeruginosa, Serratia marcescens and Enterobacter species.
MedLine Citation:
PMID:  3109815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although imipenem inhibits most bacteria at very low concentrations, some Pseudomonas aeruginosa, Serratia marcescens and Enterobacter species are resistant or become resistant after exposure. At concentrations of rifampin equivalent to those attainable in man after daily oral ingestion of 600 mg, synergy of imipenem and rifampin was found for 52% of 62 P. aeruginosa and an additive effect for 37%. Against 30 S. marcescens synergy of imipenem and rifampin was not found, but an additive effect was noted for 47% of the isolates. With 32 Enterobacter isolates 35% were synergically inhibited, and an additive effect was found against 38% of the strains. Imipenem and ciprofloxacin were synergistic for 8% of P. aeruginosa and 22% of Enterobacter. Eighty-seven percent of P. aeruginosa isolates with imipenem MIC greater than or equal to 4 micrograms/ml were synergistically inhibited by the combination of imipenem-rifampin. Imipenem MIC and MBC were lowered to 1-2 micrograms/ml and to 2-4 micrograms/ml for rifampin. MIC of imipenem and ciprofloxacin were 0.5-2 and 0.05-0.1 micrograms/ml, respectively. When a triple combination of imipenem-rifampin-ciprofloxacin was studied, 62% of P. aeruginosa, 32% of Enterobacter spp. and 47% of S. marcescens were synergistically inhibited.
Authors:
N X Chin; H C Neu
Related Documents :
9090125 - Antibacterial efficacy of new commercially manufactured disinfectant substances against...
8243035 - In vitro activity of cefpodoxime compared with other oral cephalosporins tested against...
1297465 - Sensitivity to penicillin of s. pneumoniae strains isolated from various pathological c...
7283415 - Standardized method for determining antimicrobial susceptibility of strains of ureaplas...
2056515 - Differences in subtype distribution of haemophilus influenzae type b from carriers in t...
19143975 - Drug-resistant pneumococci in children with acute lower respiratory infections in vietnam.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemotherapy     Volume:  33     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:  1987  
Date Detail:
Created Date:  1987-07-29     Completed Date:  1987-07-29     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Ciprofloxacin / pharmacology*
Drug Synergism
Enterobacter / drug effects*
Enterobacteriaceae / drug effects*
Imipenem
Microbial Sensitivity Tests
Pseudomonas aeruginosa / drug effects*
Rifampin / pharmacology*
Serratia marcescens / drug effects*
Thienamycins / pharmacology*
Chemical
Reg. No./Substance:
0/Thienamycins; 13292-46-1/Rifampin; 74431-23-5/Imipenem; 85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pulmonary vasodilator therapy for chronic obstructive pulmonary disease and cor pulmonale. Treatment...
Next Document:  Combined resistance to quinolones and beta-lactams after in vitro transfer on single drugs.