Document Detail

Synergistic and tumour selective effects of chemotherapy and ultrasound treatment.
MedLine Citation:
PMID:  16458117     Owner:  NLM     Status:  MEDLINE    
In the present work, we have analysed the effects of low frequency ultrasound exposure in combination with liposomally encapsulated doxorubicin (Caelyx) and Plurogel encapsulated fluorouracil (5-FU) on 144 Balb/c nude mice inoculated with a WiDr (human colon cancer) tumour cell line, at various concentrations. Furthermore, the theoretical foundation for the effects of ultrasound exposure of tissues and organs, and for its interaction with and enhancement of controlled release of encapsulated anticancer drugs are outlined. For the first time, it is shown that non-hyperthermic ultrasound treatment significantly increases the effect of liposomally encapsulated cytostatic drugs on tumour growth. Synergetic effects were larger for low drug concentrations, indicating that the approach may benefit patients for whom chemotherapeutic treatment gives limited effect, or for whom drug concentrations have to be restricted due to general health considerations.
Gunnar Myhr; Johan Moan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  232     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-06     Completed Date:  2006-04-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  206-13     Citation Subset:  IM    
The Norwegian Radium Hospital, Institute for Cancer Research, Montebello, 0310 Oslo, Norway.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Combined Modality Therapy
Doxorubicin / administration & dosage*
Fluorouracil / administration & dosage*
Mice, Inbred BALB C
Neoplasms, Experimental / therapy*
Ultrasonic Therapy*
Reg. No./Substance:
23214-92-8/Doxorubicin; 51-21-8/Fluorouracil

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