Document Detail

Synergistic interaction between exercise and insulin on peripheral glucose uptake.
MedLine Citation:
PMID:  7033285     Owner:  NLM     Status:  MEDLINE    
The interaction of exercise and insulin on glucose metabolism was examined in 10 healthy volunteers. Four study protocols were used: study 1: plasma insulin was raised by approximately 100 microunits/ml while plasma glucose was maintained at basal levels for 2 h (insulin clamp). Study 2: subjects performed 30 min of bicycle exercise at 40% of VO2 max. Study 3: an insulin clamp was performed as per study 1. Following 60 min of sustained hyperinsulinemia, however, subjects exercised for 30 min as per study 2. Study 4: subjects were studied as per study 3 except that catheters were inserted into the femoral artery and vein to quantitate leg glucose uptake. During the 60-90 min period of hyperinsulinemia (study 1), glucose uptake averaged 8.73 +/- 0.10 mg/kg per min. With exercise alone (study 2), the increment in peripheral glucose uptake was 1.43 +/- 0.30 mg/kg per min. When hyperinsulinemia and exercise were combined (study 3), glucose uptake averaged 15.06 +/- 0.98 mg/kg per min (P less than 0.01) and this was significantly (P less than 0.001) greater than the sum of glucose uptake when exercise and the insulin clamp were performed separately. The magnitude of rise in glucose uptake correlated closely with the increase in leg blood flow (r = 0.935, P less than 0.001), suggesting that the synergism is the result of increased blood flow and increased capillary surface area to exercising muscle. More than 85% of total body glucose metabolism during studies 1 and 3 was accounted for by skeletal muscle uptake. These results demonstrate that (a) insulin and exercise act synergistically to enhance glucose disposal in man, and (b) muscle is the primary tissue responsible for the increase in glucose metabolism following hyperinsulinemia and exercise.
R A DeFronzo; E Ferrannini; Y Sato; P Felig; J Wahren
Related Documents :
18171435 - Exercise training-induced improvements in insulin action.
3884775 - Post-exercise ketosis in post-prandial exercise: effect of glucose and alanine ingestio...
14998785 - Effect of sex on counterregulatory responses to exercise after antecedent hypoglycemia ...
16377975 - Effects of a controlled program of moderate physical exercise on insulin sensitivity in...
7889615 - Effects of follicular phase exercise on luteinizing hormone pulse characteristics in se...
11545125 - Skeletal muscle perfusion during exercise using gd-dtpa bolus detection.
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  68     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-03-13     Completed Date:  1982-03-13     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1468-74     Citation Subset:  AIM; IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Glucose / metabolism*
Hyperinsulinism / metabolism
Infusions, Parenteral
Insulin / administration & dosage,  metabolism*
Muscles / metabolism*
Physical Exertion*
Regional Blood Flow
Time Factors
Grant Support
1-F05-TW02716-01/TW/FIC NIH HHS
Reg. No./Substance:
11061-68-0/Insulin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensi...
Next Document:  Sites of tissue binding and uptake in vivo of bacterial lipopolysaccharide-high density lipoprotein ...