Document Detail

Synergistic interaction of alpha 1- and beta-adrenoceptor agonists on induction arrhythmias during halothane anesthesia in dogs.
MedLine Citation:
PMID:  2897809     Owner:  NLM     Status:  MEDLINE    
The authors investigated the role of alpha 1- and beta-adrenoceptors on the induction of arrhythmias during halothane anesthesia in the dog. The arrhythmogenic doses (ADs) of various combinations of alpha 1- and beta-adrenoceptor agonists were determined in dogs (N = 105) during halothane anesthesia. Isoproterenol (ISP) and phenylephrine (PHE) administered separately failed to induce arrhythmias in doses up to 4 micrograms/kg and 200 micrograms/kg, respectively. The interaction between ISP and PHE in inducing arrhythmias showed typical hyperbolic isoboles. At a systolic pressure of 140 mmHg, the AD of ISP in the presence of PHE was significantly lower than that in the presence of angiotensin II (ANG II). At a systolic pressure of 150, 160, 170, or 180 mmHg, there was no significant difference between the AD of ISP in the presence of PHE and that in the presence of ANG II. Increasing heart rate by electrical pacing did not replace ISP in the arrhythmogenic interaction between ISP and PHE. The results indicate that both alpha 1- and beta-adrenoceptor agonists are important for producing arrhythmias during halothane anesthesia, and that these agonists synergistically interact on the heart by different mechanisms.
Y Hayashi; K Sumikawa; C Tashiro; I Yoshiya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  68     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-07-06     Completed Date:  1988-07-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  902-7     Citation Subset:  AIM; IM    
Department of Anesthesiology, Osaka University Medical School, Japan.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology*
Adrenergic beta-Agonists / pharmacology*
Anesthesia, Inhalation*
Arrhythmias, Cardiac / chemically induced*
Drug Synergism
Isoproterenol / pharmacology
Phenylephrine / pharmacology
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Agonists; 151-67-7/Halothane; 59-42-7/Phenylephrine; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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