Document Detail

Synergistic interaction of adenosine diphosphate-epinephrine and epinephrine-collagen in aggregation of human platelets.
MedLine Citation:
PMID:  15631365     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Efficient hemostasis in human body depends on a complicated series of events which actively involve blood platelets. Platelets exhibit diverse responses in a variety of agonists. In vivo, most of the agonists act in synergism, causing aggregation of platelets. METHODS: In this study, the synergism between ADP-Epinephrine and Epinephrine-Collagen has been determined by means of turbidometric method, which measures changes in optical density of platelet suspension. The study was carried out at the department of Hematology, Armed Forces Institute of Pathology, Rawalpindi. The subthreshold concentrations of each of the agonists were established with the help of dose response curve. By adding these agonists in subthreshold concentrations, the synergism between ADP-Epinephrine and Epinephrine-Collagen was determined. RESULTS: The combinations of these agonists in subthreshold levels showed the synergistic responses in causing platelet aggregation. CONCLUSION: These findings indicate that the optimal platelet aggregation does occur between the above mentioned pairs of agonists even when each of the agonist is added to the other in subthreshold doses.
Muhammad Shamaun Razi; Idrees Farooq Butt; Muhammad Ayub; Muhammad Aslam; Waqas Hameed; Ahmed Badar; Muhammad Nasir Afzal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of Ayub Medical College, Abbottabad : JAMC     Volume:  16     ISSN:  1025-9589     ISO Abbreviation:  J Ayub Med Coll Abbottabad     Publication Date:    2004 Jul-Sep
Date Detail:
Created Date:  2005-01-05     Completed Date:  2005-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910750     Medline TA:  J Ayub Med Coll Abbottabad     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  20-4     Citation Subset:  IM    
Department of Physiology, Shifa College of Medicine, Islamabad.
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MeSH Terms
Adenosine Diphosphate / physiology*
Cell Culture Techniques
Collagen / physiology*
Epinephrine / physiology*
Middle Aged
Platelet Aggregation / physiology*
Reference Values
Reg. No./Substance:
51-43-4/Epinephrine; 58-64-0/Adenosine Diphosphate; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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