Document Detail


Synergistic inhibition of LDL oxidation by phytoestrogens and ascorbic acid.
MedLine Citation:
PMID:  10962208     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Increasing evidence indicates that oxidative modification of low-density lipoprotein (LDL) is an important determinant in atherogenesis, and following menopause, the incidence of coronary heart disease is as prevalent in women as it is in men. Estrogen has been demonstrated to inhibit the susceptibility of LDL to be oxidized, and more recently the use of phytoestrogens has been considered for estrogen replacement therapy. In this study the antioxidant activity of the three major phytoestrogens: genistein, daidzein, and equol were measured in terms of LDL oxidative susceptibility. Increasing levels of genistein, daidzein, and equol inhibited LDL oxidation, and this inhibitory effect was further enhanced in the presence of ascorbic acid. The synergism exhibited by these compounds is of clinical importance to phytoestrogen therapy since the efficacy of phytoestrogens as effective antioxidants is evident at concentration well within the range found in the plasma of subjects consuming soy products. However, this synergism, combined with the low reactivity of the phytoestrogens with peroxyl radicals, suggests that an antioxidant mechanism other then free radical scavenging reactions account for the phytoestrogen antioxidant effect. A structural basis for inhibition of LDL oxidation involving interaction of the phytoestrogens with apoB-100 is postulated.
Authors:
J Hwang; A Sevanian; H N Hodis; F Ursini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  29     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-10-18     Completed Date:  2000-10-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  79-89     Citation Subset:  IM    
Affiliation:
University of Southern California, Department of Molecular Pharmacology and Toxicology, School of Pharmacy, and the Atherosclerosis Research Unit, Division of Cardiology, Los Angeles, CA 90089, USA. julianah@hsc.usc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / pharmacology
Ascorbic Acid / pharmacology*
Chromans / chemistry,  pharmacology
Drug Synergism
Estrogens, Non-Steroidal / pharmacology*
Female
Genistein / chemistry,  pharmacology
Humans
Isoflavones / chemistry,  pharmacology
Kinetics
Lipid Peroxidation / drug effects
Lipid Peroxides / metabolism
Lipoproteins, LDL / blood*,  drug effects*
Male
Oxidation-Reduction
Phytoestrogens
Plant Preparations
Grant Support
ID/Acronym/Agency:
HL50350/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Chromans; 0/Estrogens, Non-Steroidal; 0/Isoflavones; 0/Lipid Peroxides; 0/Lipoproteins, LDL; 0/Phytoestrogens; 0/Plant Preparations; 0/oxidized low density lipoprotein; 446-72-0/Genistein; 486-66-8/daidzein; 50-81-7/Ascorbic Acid; 531-95-3/equol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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