| Synergistic effects of triterpenic compounds with prostaglandin A1 on vaccinia virus infected L929 cells. | |
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MedLine Citation:
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PMID: 9477119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Triterpenic compounds, such as glycyrrhizic acid (GRa) and carbenoxolone (CBX), have a synergistic effect with prostaglandin A1 on the inhibition of vaccinia virus (VV) replication in L929 cells. The fractional inhibitory concentration (FIC) values for GRa and CBX were 0.5 and 0.25, respectively. In the supernatant of triterpene treated cells, increased production of some prostaglandins was shown, whilst cell-associated prostaglandins and prostaglandins of the A series were only slightly influenced by the presence of triterpenes. From these findings there is no evidence that prostaglandin production and metabolism could be involved in the antiviral activity of triterpenes. |
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Authors:
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G Lampis; A Ingianni; R Pompei |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Antiviral research Volume: 36 ISSN: 0166-3542 ISO Abbreviation: Antiviral Res. Publication Date: 1997 Dec |
Date Detail:
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Created Date: 1998-03-26 Completed Date: 1998-03-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109699 Medline TA: Antiviral Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 191-5 Citation Subset: IM |
Affiliation:
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Sezione di Microbiologia Applicata, Istituto di Medicina Interna, Universita' di Cagliari, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbenoxolone / pharmacology*, toxicity Cell Line Cercopithecus aethiops Drug Synergism Glycyrrhizic Acid / pharmacology*, toxicity Mice Molecular Structure Prostaglandins / biosynthesis Prostaglandins A / pharmacology* Vaccinia virus / drug effects* Vero Cells |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins; 0/Prostaglandins A; 1405-86-3/Glycyrrhizic Acid; 14152-28-4/prostaglandin A1; 5697-56-3/Carbenoxolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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