Document Detail


Synergistic effects of triterpenic compounds with prostaglandin A1 on vaccinia virus infected L929 cells.
MedLine Citation:
PMID:  9477119     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Triterpenic compounds, such as glycyrrhizic acid (GRa) and carbenoxolone (CBX), have a synergistic effect with prostaglandin A1 on the inhibition of vaccinia virus (VV) replication in L929 cells. The fractional inhibitory concentration (FIC) values for GRa and CBX were 0.5 and 0.25, respectively. In the supernatant of triterpene treated cells, increased production of some prostaglandins was shown, whilst cell-associated prostaglandins and prostaglandins of the A series were only slightly influenced by the presence of triterpenes. From these findings there is no evidence that prostaglandin production and metabolism could be involved in the antiviral activity of triterpenes.
Authors:
G Lampis; A Ingianni; R Pompei
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antiviral research     Volume:  36     ISSN:  0166-3542     ISO Abbreviation:  Antiviral Res.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-26     Completed Date:  1998-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109699     Medline TA:  Antiviral Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  191-5     Citation Subset:  IM    
Affiliation:
Sezione di Microbiologia Applicata, Istituto di Medicina Interna, Universita' di Cagliari, Italy.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbenoxolone / pharmacology*,  toxicity
Cell Line
Cercopithecus aethiops
Drug Synergism
Glycyrrhizic Acid / pharmacology*,  toxicity
Mice
Molecular Structure
Prostaglandins / biosynthesis
Prostaglandins A / pharmacology*
Vaccinia virus / drug effects*
Vero Cells
Chemical
Reg. No./Substance:
0/Prostaglandins; 0/Prostaglandins A; 1405-86-3/Glycyrrhizic Acid; 14152-28-4/prostaglandin A1; 5697-56-3/Carbenoxolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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