| Synergistic effects of prenatal hypoxia and postnatal high fat diet in the development of cardiovascular pathology in young rats. | |
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MedLine Citation:
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PMID: 22739349 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We have previously shown that adult offspring exposed to a prenatal hypoxic insult leading to IUGR are more susceptible to cardiovascular pathologies. Our objectives were to evaluate the interaction between hypoxia-induced IUGR and post-natal diet in the early development of cardiovascular pathologies. Furthermore, we sought to determine whether the postnatal administration of resveratrol could prevent the development of cardiovascular disorders associated with hypoxia-induced IUGR. On day 15 of pregnancy, Sprague Dawley rats were randomly assigned to hypoxia (11.5% oxygen), to induce IUGR, or normal oxygen (Control) groups. For study A: male offspring (3 weeks of age) were randomly assigned low fat (LF, <10% fat) or high fat (HF, 45% fat) diet. For study B: offspring were randomized to either HF or HF+Resveratrol diets. After 9 weeks, cardiac and vascular function was evaluated. Prenatal hypoxia and HF diet were associated with an increased myocardial susceptibility to ischemia. Blood pressure, in vivo cardiac function and ex vivo vascular function were not different among experimental groups, however, hypoxia-induced IUGR offspring had lower resting heart rates. Our results suggest that prenatal insults can enhance the susceptibility to a second hit such as myocardial ischemia, and that this phenomenon is exacerbated, in the early stages of life by nutritional stressors such as a HF diet. Supplementing HF diets with resveratrol improved cardiac tolerance to ischemia in offspring born IUGR but not in controls. Thus, we conclude that the additive effect of prenatal (hypoxia-induced IUGR) and postnatal (HF diet) factors can lead to the earlier development of cardiovascular pathology in rats and postnatal resveratrol supplementation prevented the deleterious cardiovascular effects of HF diet in offspring exposed to prenatal hypoxia. |
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Authors:
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Christian F Rueda-Clausen; Jude S Morton; Vernon W Dolinsky; Jason R B Dyck; Sandra T Davidge |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-27 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Alberta. |
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