Document Detail

Synergistic effects of focus ultrasound with different frequency and hematoporphyrin on human tumor cells.
MedLine Citation:
PMID:  18726234     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Human hematopoietic cell K(562), human melenoma cell LiBr and human stomach cancer cells were exposed to ultrasound (US, 1.75 W/cm(2), 1.4, 2.16 and 2.4 MHz)in vitro in the presence or absence of hematoporphyrin (Hp, 100 microg/mL). The cell damaging effects of treatments were determined by means of the Trypan Blue dye exclusion test, MTT test and FDA test. The experimental results showed that the same cell line had different sensibilities to the US of different frequencies, and different cell line had different damage at the same acoustical radiation. The combined treatment with US and Hp enhanced greatly the cell damage, and no sensibility of insonation cells to US with Hp was observed. The cell damage tests showed that the results of MTT test corresponded well with that of Trypan Blue dye test.
H Qi; S Tan; Y Ma; C Song
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Science in China. Series C, Life sciences / Chinese Academy of Sciences     Volume:  41     ISSN:  1006-9305     ISO Abbreviation:  Sci. China, C, Life Sci.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2009-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9611809     Medline TA:  Sci China C Life Sci     Country:  China    
Other Details:
Languages:  eng     Pagination:  520-4     Citation Subset:  -    
Shaanxj Normal University, Xi'an, China.
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