Document Detail

Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans.
MedLine Citation:
PMID:  23033993     Owner:  NLM     Status:  In-Data-Review    
Context: Exposure to single pollutants e.g. particulate matter (PM) is associated with adverse health effects, but it does not represent a real world scenario that usually involves multiple pollutants. Objectives: Determine if simultaneous exposure to PM and NO(2) results in synergistic interactions. Materials and methods: Healthy young volunteers were exposed to clean air, nitrogen dioxide (NO(2), 0.5 ppm), concentrated fine particles from Chapel Hill air (PM(2.5)CAPs, 89.5 ± 10.7 µg/m(3)), or NO(2)+PM(2.5)CAPs for 2 h. Each subject performed intermittent exercise during the exposure. Parameters of heart rate variability (HRV), changes in repolarization, peripheral blood endpoints and lung function were measured before and 1 and 18 h after exposure. Bronchoalveolar lavage (BAL) was performed 18 h after exposure. Results: NO(2) exposure alone increased cholesterol and HDL 18 h after exposure, decreased high frequency component of HRV one and 18 h after exposure, decreased QT variability index 1 h after exposure, and increased LDH in BAL fluid. The only significant change with PM(2.5)CAPs was an increase in HDL 1 h after exposure, likely due to the low concentrations of PM(2.5)CAPs in the exposure chamber. Exposure to both NO(2) and PM(2.5)CAPs increased BAL α1-antitrypsin, mean t wave amplitude, the low frequency components of HRV and the LF/HF ratio. These changes were not observed following exposure to NO(2) or PM(2.5)CAPs alone, suggesting possible interactions between the two pollutants. Discussion and conclusions: NO(2) exposure may produce and enhance acute cardiovascular effects of PM(2.5)CAPs. Assessment of health effects by ambient PM should consider its interactions with gaseous copollutants.
Yuh-Chin T Huang; Ana G Rappold; Donald W Graff; Andrew J Ghio; Robert B Devlin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inhalation toxicology     Volume:  24     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  790-7     Citation Subset:  IM    
Department of Medicine, Duke University Medical Center , Durham, NC , USA.
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