| Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans. | |
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MedLine Citation:
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PMID: 23033993 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Context: Exposure to single pollutants e.g. particulate matter (PM) is associated with adverse health effects, but it does not represent a real world scenario that usually involves multiple pollutants. Objectives: Determine if simultaneous exposure to PM and NO(2) results in synergistic interactions. Materials and methods: Healthy young volunteers were exposed to clean air, nitrogen dioxide (NO(2), 0.5 ppm), concentrated fine particles from Chapel Hill air (PM(2.5)CAPs, 89.5 ± 10.7 µg/m(3)), or NO(2)+PM(2.5)CAPs for 2 h. Each subject performed intermittent exercise during the exposure. Parameters of heart rate variability (HRV), changes in repolarization, peripheral blood endpoints and lung function were measured before and 1 and 18 h after exposure. Bronchoalveolar lavage (BAL) was performed 18 h after exposure. Results: NO(2) exposure alone increased cholesterol and HDL 18 h after exposure, decreased high frequency component of HRV one and 18 h after exposure, decreased QT variability index 1 h after exposure, and increased LDH in BAL fluid. The only significant change with PM(2.5)CAPs was an increase in HDL 1 h after exposure, likely due to the low concentrations of PM(2.5)CAPs in the exposure chamber. Exposure to both NO(2) and PM(2.5)CAPs increased BAL α1-antitrypsin, mean t wave amplitude, the low frequency components of HRV and the LF/HF ratio. These changes were not observed following exposure to NO(2) or PM(2.5)CAPs alone, suggesting possible interactions between the two pollutants. Discussion and conclusions: NO(2) exposure may produce and enhance acute cardiovascular effects of PM(2.5)CAPs. Assessment of health effects by ambient PM should consider its interactions with gaseous copollutants. |
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Authors:
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Yuh-Chin T Huang; Ana G Rappold; Donald W Graff; Andrew J Ghio; Robert B Devlin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Inhalation toxicology Volume: 24 ISSN: 1091-7691 ISO Abbreviation: Inhal Toxicol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8910739 Medline TA: Inhal Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 790-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Duke University Medical Center , Durham, NC , USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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