Document Detail


Synergistic effects of apolipoprotein E gene epsilon polymorphism and some conventional risk factors on premature ischaemic heart disease development.
MedLine Citation:
PMID:  17975753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ischaemic heart disease (IHD), which is a clinical manifestation of atherosclerotic changes in coronary arteries, results from the action of multiple genetic and environmental factors. Genetic susceptibility to IHD may be determined by specific polymorphic variants of genes encoding isoforms involved in processes important in the pathogenesis of atherosclerosis. Due to the multifactorial nature of IHD, participation of a single polymorphism in the determination of the disease risk is relatively small. However, it seems that its significance may increase in the presence of a specific genetic or environmental background. AIM: To evaluate a possible association between the epsilon polymorphism of the apolipoprotein E gene (apo E) and premature IHD in the Polish population as well as to determine whether the genotype may modulate the influence of conventional risk factors on IHD. METHODS: We studied 247 caucasian subjects: 140 patients with angiographically confirmed IHD and 107 blood donors without a history of IHD. Polymorphism epsilon of the apo E gene was genotyped using the PCR-RFLP method. RESULTS: We observed a tendency to a higher prevalence of the epsilon4 allele and carriers of this allele in the IHD group compared to controls. However, these differences were not statistically significant. We also observed a synergistic effect between epsilon4 allele carrier state and smoking, elevated level of total cholesterol and, to a lower degree - LDL cholesterol, on IHD risk. CONCLUSION: Presented data show the synergistic effects between epsilon4 allele carrier state and some traditional risk factors on determining the risk of premature coronary artery disease.
Authors:
Anna Balcerzyk; Iwona Zak; Jolanta Krauze
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kardiologia polska     Volume:  65     ISSN:  0022-9032     ISO Abbreviation:  Kardiol Pol     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-11-02     Completed Date:  2008-04-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376352     Medline TA:  Kardiol Pol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  1058-65; discussion 1066-7     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Medical Genetics, Medical University of Silesia, Katowice, Poland. abalcerzyk@slam.katowice.pl
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MeSH Terms
Descriptor/Qualifier:
Adult
Anticipation, Genetic
Apolipoproteins E / genetics*
Case-Control Studies
Coronary Angiography
Female
Genetic Predisposition to Disease*
Genotype
Humans
Male
Middle Aged
Myocardial Ischemia / genetics*,  radiography
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length*
Protein Isoforms
Risk Factors
Chemical
Reg. No./Substance:
0/Apolipoproteins E; 0/Protein Isoforms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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