| Synergistic effect of released aspirin/heparin for preventing bovine pericardial calcification. | |
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MedLine Citation:
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PMID: 10718766 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Calcification is a frequent cause of the clinical failure of bioprosthetic heart valves fabricated from glutaraldehyde pretreated bovine pericardium (GATBP). Aspirin, a potent antiplatelet drug, and heparin, an anticoagulant, are commonly used for postimplant complications such as thrombosis and thromboembolism. Aspirin and heparin were embedded in chitosan/polyethylene vinylacetate co-matrix to develop a prolonged release form. The effect of these drugs towards the bioprosthetic calcification was investigated by in vitro and in vivo models. In vitro and in vivo evaluation suggest that the released aspirin/heparin from the co-matrix had a synergistic effect in inhibiting GATBP calcification. In vivo subcutaneous co-implantation was performed with PEG-20,000 grafted bovine pericardium (PEG-GABP), aspirin, and heparin. Biochemical, histological, and scanning electron microscopic evaluation of retrieved samples demonstrated a significant reduction in calcium deposition and alkaline phosphatase activity on PEG-GABP compared to GATBP. It seems that the aspirin/heparin combination synergistically inhibits the pericardial calcification in addition to their antithrombotic function. |
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Authors:
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S C Vasudev; T Chandy; C P Sharma; M Mohanty; P R Umasankar |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Artificial organs Volume: 24 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-04-04 Completed Date: 2000-04-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 129-36 Citation Subset: IM |
Affiliation:
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Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojappura, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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analysis Animals Anticoagulants / administration & dosage, therapeutic use* Aspirin / administration & dosage, therapeutic use* Biopolymers Bioprosthesis* Calcinosis / prevention & control* Calcium / analysis Cattle Chitin / analogs & derivatives Chitosan Delayed-Action Preparations Drug Delivery Systems Drug Synergism Heart Valve Prosthesis* Heparin / administration & dosage, therapeutic use* Male Microscopy, Electron, Scanning Pericardium* / chemistry, ultrastructure Platelet Aggregation Inhibitors / administration & dosage, therapeutic use* Polyethylene Glycols Polyvinyls Prosthesis Failure Rats Rats, Wistar Surface-Active Agents |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Biopolymers; 0/Delayed-Action Preparations; 0/Platelet Aggregation Inhibitors; 0/Polyethylene Glycols; 0/Polyvinyls; 0/Surface-Active Agents; 1398-61-4/Chitin; 24937-78-8/ethylenevinylacetate copolymer; 50-78-2/Aspirin; 7440-70-2/Calcium; 9005-49-6/Heparin; 9012-76-4/Chitosan; EC 3.1.3.1/Alkaline Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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