| Synergistic effect of melatonin on exercise-induced neuronal reconstruction and functional recovery in a spinal cord injury animal model. | |
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MedLine Citation:
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PMID: 20210855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide (NO) may aggravate neuronal damage after spinal cord injury (SCI). We hypothesized that NO produced by inducible nitric oxide synthase (iNOS) accelerates secondary damage to spinal tissue, which may be reversed by the neuroprotectant, melatonin. This study investigated the effects of combination therapy with melatonin (10 mg/kg) and exercise (10 m/min) on recovery from SCI caused by contusion. We examined locomotor recovery, iNOS gene expression, autophagic and apoptotic signaling, including Beclin-1, LC3, p53 and IKKalpha protein expression and histological alterations in the ventral horn of the spinal cord. Melatonin in combination with exercise resulted in significantly increased hindlimb movement (P < 0.05), a reduced level of iNOS mRNA (P < 0.05) and more motor neurons in the ventral horn, versus control SCI and SCI plus exercise alone, with no effect on the other signaling molecules examined. This study shows that combined therapy with melatonin and exercise reduces the degree of secondary damage associated with SCI in rats and supports the possible use of melatonin in combination with exercise to reduce the side effects related to exercise-induced fatigue and impairment. |
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Authors:
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Kanghui Park; Youngjeon Lee; Sookyoung Park; Seunghoon Lee; Yunkyung Hong; Sang- Kil Lee; Yonggeun Hong |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-04 |
Journal Detail:
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Title: Journal of pineal research Volume: 48 ISSN: 1600-079X ISO Abbreviation: J. Pineal Res. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-08-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504412 Medline TA: J Pineal Res Country: Denmark |
Other Details:
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Languages: eng Pagination: 270-81 Citation Subset: IM |
Affiliation:
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Department of Rehabilitation Science in Interdisciplinary PhD Program, Inje University, Gimhae, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blotting, Western Body Weight / drug effects Disease Models, Animal Drug Synergism Exercise Therapy* Histocytochemistry Male Melatonin / pharmacology* Motor Activity / drug effects Muscle, Skeletal / metabolism Myocardium / metabolism Nitric Oxide / metabolism Nitric Oxide Synthase Type II / genetics, metabolism Rats Rats, Sprague-Dawley Spinal Cord / pathology Spinal Cord Injuries / drug therapy, metabolism, therapy* Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 73-31-4/Melatonin; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nos2 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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