Document Detail


Synergistic effect of human relaxin and progesterone on human myometrial contractions.
MedLine Citation:
PMID:  6125435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an in vitro human myometrial strip system, both relaxin and progesterone can independently decrease the amplitude of spontaneous myometrial contractions. However, progesterone and relaxin synergize in this action. Doses of relaxin and progesterone which independently are ineffective, together inhibit myometrial contraction amplitude. Relaxin and progesterone are both products of the corpus luteum, a structure necessary for early pregnancy maintenance. The synergistic action of relaxin and progesterone in vitro suggests a similar in vivo physiologic effect in establishing uterine quiescence.
Authors:
P Beck; P Adler; N Szlachter; L T Goldsmith; B G Steinetz; G Weiss
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  20     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Corpus Luteum / physiology
Drug Synergism
Female
Humans
Progesterone / pharmacology*
Relaxin / pharmacology*
Uterine Contraction / drug effects*
Grant Support
ID/Acronym/Agency:
HD-12395/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
57-83-0/Progesterone; 9002-69-1/Relaxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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