Document Detail

Synergistic effect of hepatitis virus infection and occupational exposures to vinyl chloride monomer and ethylene dichloride on serum aminotransferase activity.
MedLine Citation:
PMID:  14504367     Owner:  NLM     Status:  MEDLINE    
AIMS: To study the synergistic effect of occupational chemical exposure and hepatitis virus infection on serum aminotransferase activity. METHODS: A total of 568 male workers who were employed in five polyvinyl chloride (PVC) or four vinyl chloride monomer (VCM) manufacturing factories were studied. Information relating to current job title, alcohol consumption, and cigarette smoking was obtained. Exposure level of chemical mixtures was classified by hygienic effect (a summation of personal time weighted average/reference permissible exposure level of each chemical) into high, moderate, and low exposure groups. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), and anti-hepatitis C antibody were assayed. RESULTS: Hepatitis virus infection and increased body mass index were associated with abnormal serum aminotransferase activity. In workers with hepatitis virus infection, those with high exposure had a higher prevalence of abnormal AST and ALT compared to low exposure; among those without hepatitis virus infection, the differences of prevalence of abnormal AST and ALT were not significant between different chemical exposure groups. There was a significant trend of increasing risks of increased AST and ALT in moderate and high exposure groups with hepatitis virus infection. Such a synergistic effect was more prominent among HBeAg-positive workers. CONCLUSIONS: Mixed exposures to 1,2-ethylene dichloride and VCM have a positive synergistic effect with hepatitis virus infection on liver damage. Assessment of fitness for work should be considered in workers with hepatitis B and C infection, when they have potential exposure to hepatotoxins in the workplace.
H-I Hsieh; J-D Wang; P-C Chen; T-J Cheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  60     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-09-23     Completed Date:  2003-10-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  774-8     Citation Subset:  IM    
Department of Family Medicine, Cathay General Hospital, Taipei, Taiwan.
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MeSH Terms
Biological Markers / blood
Ethylene Dichlorides / adverse effects*
Hepatitis, Viral, Human / blood,  chemically induced,  enzymology*
Middle Aged
Occupational Exposure / adverse effects*
Regression Analysis
Transaminases / blood*
Vinyl Chloride / adverse effects*
Reg. No./Substance:
0/Biological Markers; 0/Ethylene Dichlorides; 107-06-2/ethylene dichloride; 75-01-4/Vinyl Chloride; EC 2.6.1.-/Transaminases

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