| Synergistic effect of decreased opioid activity and sleep deprivation on head-twitch response in mice. | |
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MedLine Citation:
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PMID: 20399224 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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In schizophrenia, an opioidergic understimulation and a decreased sleep duration are found. The pathogenic significance of these factors is unknown. The present study assessed the influence of the combination of the factors on serotonergic 2A (5-HT(2A)) receptors that are possibly related to psychosis development. 2,5-dimethoxy-4-iodoamphetamine (DOI)-induced head-twitch response in mice was used as a model of 5-HT(2A) receptor functioning. Mice underwent sleep deprivation and/or a blockade of opioidergic receptors with naloxone. To evaluate the involvement of 5-HT(2A) receptor in effects observed, animals were pretreated with MDL 100,907, a potent and selective antagonist of 5-HT(2A) receptor. As was found, 4h of sleep deprivation followed by administration of naloxone significantly increases the frequency of head twitches, with sleep deprivation and naloxone being ineffective alone. The action of the "sleep deprivation-opioid understimulation" combination is antagonized completely by MDL 100,907. Thus, some schizophrenia-associated factors can synergistically enhance the activity of 5-HT(2A) receptors. These results suggest the above factors being pathogenically relevant in schizophrenia. |
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Authors:
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Ilya D Ionov |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-04-14 |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 96 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
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Languages: eng Pagination: 48-51 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Centre on Theoretical Problems in Physical and Chemical Pharmacology, Russian Academy of Sciences, Moscow, Russia. canyon1@rol.ru |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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