| Synergistic cytotoxicity between dimethyl sulfoxide and antineoplastic agents against ovarian cancer in vitro. | |
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MedLine Citation:
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PMID: 3177534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dimethyl sulfoxide is a well-known differentiating agent that has been shown to inhibit tumor growth in vitro. We hypothesized that antineoplastic agents might show synergistic cytotoxicity when combined with 10% dimethyl sulfoxide. Twenty-four malignant ovarian tumors were removed and used in tests to determine the cytotoxicities of 10% dimethyl sulfoxide alone, each of six antineoplastic agents alone, and 10% dimethyl sulfoxide plus each antineoplastic agent. Cytotoxicity results for 10% dimethyl sulfoxide alone and each antineoplastic agent alone were used to evaluate each combination of dimethyl sulfoxide and an antineoplastic agent for synergy. There were 14 synergistic responses that were statistically significant at the p less than 0.01 confidence level between 10% dimethyl sulfoxide and an antineoplastic agent against the ovarian tumors. Seven of these responses were significant at the p less than 0.0003 level. This is strong evidence that true synergistic cytotoxicity occurs when an antineoplastic agent is combined with 10% dimethyl sulfoxide. We conclude that intraperitoneal delivery of antineoplastic agents in 10% dimethyl sulfoxide may be useful in the treatment of certain ovarian cancers. |
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Authors:
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R F Pommier; E A Woltering; G Milo; W S Fletcher |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 159 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-11-23 Completed Date: 1988-11-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 848-52 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Oregon Health Sciences University, Portland 97201. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anthraquinones
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administration & dosage,
pharmacology Antineoplastic Agents / administration & dosage*, pharmacology Cisplatin / administration & dosage, pharmacology Dimethyl Sulfoxide / administration & dosage*, pharmacology Doxorubicin / administration & dosage, pharmacology Drug Synergism Female Fluorouracil / administration & dosage, pharmacology Humans Methotrexate / administration & dosage, pharmacology Ovarian Neoplasms / drug therapy, pathology* Tumor Cells, Cultured / drug effects Vinblastine / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anthraquinones; 0/Antineoplastic Agents; 15663-27-1/Cisplatin; 23214-92-8/Doxorubicin; 51-21-8/Fluorouracil; 59-05-2/Methotrexate; 67-68-5/Dimethyl Sulfoxide; 84-65-1/9,10-anthraquinone; 865-21-4/Vinblastine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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