Document Detail

Synergistic cytotoxic action of vitamin C and vitamin K3.
MedLine Citation:
PMID:  11848506     Owner:  NLM     Status:  MEDLINE    
We investigated the combination effect of sodium ascorbate (vitamin C) and menadione (vitamin K3) on the viability of various cultured cells. Human oral squamous cell carcinoma (HSC-2, HSC-3) and human promyelocytic leukemia (HL-60) cells were more sensitive to these vitamins as compared to normal cells (human gingival fibroblast HGF, human periodontal ligament fibroblast HPLF, human pulp cell HPC). The combination of vitamin C and vitamin K3 produced synergistic cytotoxicity against all these 6 cell lines. Treatment with vitamin C or vitamin K3, or their combination, induced internucleosomal DNA fragmentation only in HL-60 cells, but not in the oral tumor cell lines (HSC-2, HSC-3, HSG). ESR spectroscopy showed that vitamins C and K3 produce radicals under alkaline conditions and that the combination of these two vitamins synergistically enhanced their respective radical intensities.
W Zhang; T Negoro; K Satoh; Y Jiang; K Hashimoto; H Kikuchi; H Nishikawa; T Miyata; Y Yamamoto; K Nakano; E Yasumoto; T Nakayachi; K Mineno; T Satoh; H Sakagami
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  21     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2001 Sep-Oct
Date Detail:
Created Date:  2002-02-18     Completed Date:  2002-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  3439-44     Citation Subset:  IM    
Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology, Beijing, China.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / pharmacology*
Ascorbic Acid / administration & dosage,  pharmacology*
Carcinoma, Squamous Cell / drug therapy,  metabolism
DNA Fragmentation / drug effects
Dose-Response Relationship, Drug
Drug Synergism
Electron Spin Resonance Spectroscopy
Fibroblasts / drug effects,  metabolism
HL-60 Cells / drug effects,  metabolism
Mouth Neoplasms / drug therapy,  metabolism
Tumor Cells, Cultured
Vitamin K 3 / administration & dosage,  pharmacology*
Reg. No./Substance:
50-81-7/Ascorbic Acid; 58-27-5/Vitamin K 3

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