| Synergistic antitumor effect of β-elemene and etoposide is mediated via induction of cell apoptosis and cell cycle arrest in non-small cell lung carcinoma cells. | |
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MedLine Citation:
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PMID: 21904777 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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β-Elemene, an anticancer agent, was isolated from the traditional Chinese medicine plant, curcuma aromatica. In this study, we investigated the synergistic antitumor effect of β-elemene and etoposide phosphate (VP-16) in A549 non-small cell lung carcinoma cells. The cells were treated with β-elemene (20 or 50 µg/ml), VP-16 (15 µg/ml) or the combination of both for 24 h. Compared to the treatment with β-elemene or VP-16 alone, an increased antitumor activity was observed with the combination of both, which was mediated by the cleavage of PARP, the up-regulation of Bax, p53 and p21, and the suppression of cyclin D1. These results suggest that the combination of β-elemene and VP-16 may be a promising therapeutic option for lung cancer. |
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Authors:
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Fan Zhang; Ling Xu; Xiujuan Qu; Mingfang Zhao; Bo Jin; Jian Kang; Yunpeng Liu; Xuejun Hu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-07-20 |
Journal Detail:
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Title: Molecular medicine reports Volume: 4 ISSN: 1791-3004 ISO Abbreviation: Mol Med Rep Publication Date: 2011 Nov-Dec |
Date Detail:
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Created Date: 2011-09-09 Completed Date: 2012-01-09 Revised Date: 2013-02-22 |
Medline Journal Info:
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Nlm Unique ID: 101475259 Medline TA: Mol Med Rep Country: Greece |
Other Details:
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Languages: eng Pagination: 1189-93 Citation Subset: IM |
Affiliation:
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Department of Respiratory Medicine, The First Hospital of China Medical University, Shenyang 110001, PR China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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therapeutic use,
toxicity* Apoptosis / drug effects* Carcinoma, Non-Small-Cell Lung / drug therapy*, metabolism Cell Cycle Checkpoints / drug effects* Cell Line, Tumor Curcuma / chemistry Cyclin D1 / metabolism Cyclin-Dependent Kinase Inhibitor p21 / metabolism Etoposide / analogs & derivatives*, therapeutic use, toxicity Humans Lung Neoplasms / drug therapy*, metabolism Organophosphorus Compounds / therapeutic use, toxicity* Poly(ADP-ribose) Polymerases / metabolism Sesquiterpenes / therapeutic use, toxicity* Tumor Suppressor Protein p53 / metabolism bcl-2-Associated X Protein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Organophosphorus Compounds; 0/Sesquiterpenes; 0/Tumor Suppressor Protein p53; 0/bcl-2-Associated X Protein; 0/beta-elemene; 117091-64-2/etoposide phosphate; 136601-57-5/Cyclin D1; 33419-42-0/Etoposide; EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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