Document Detail

Synergistic activities of an efflux pump inhibitor and iron chelators against Pseudomonas aeruginosa growth and biofilm formation.
MedLine Citation:
PMID:  20566773     Owner:  NLM     Status:  MEDLINE    
The efflux pump inhibitor phenyl-arginine-beta-naphthylamide (PAbetaN) was paired with iron chelators 2,2'-dipyridyl, acetohydroxamic acid, and EDTA to assess synergistic activities against Pseudomonas aeruginosa growth and biofilm formation. All of the tested iron chelators synergistically inhibited P. aeruginosa growth and biofilm formation with PAbetaN. PAbetaN-EDTA showed the most promising activity against P. aeruginosa growth and biofilm formation.
Yang Liu; Liang Yang; Søren Molin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-21
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  54     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-12-01     Revised Date:  2011-07-25    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3960-3     Citation Subset:  IM    
Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark.
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MeSH Terms
2,2'-Dipyridyl / pharmacology
Anti-Bacterial Agents / pharmacology*
Biofilms / drug effects*,  growth & development*
Dipeptides / pharmacology
Drug Synergism
Edetic Acid / pharmacology
Hydroxamic Acids / pharmacology
Iron Chelating Agents / pharmacology*
Pseudomonas aeruginosa / drug effects*,  growth & development*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Dipeptides; 0/Hydroxamic Acids; 0/Iron Chelating Agents; 0/phenylalanine arginine beta-naphthylamide; 366-18-7/2,2'-Dipyridyl; 546-88-3/acetohydroxamic acid; 60-00-4/Edetic Acid

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