| Synergistic activities of an efflux pump inhibitor and iron chelators against Pseudomonas aeruginosa growth and biofilm formation. | |
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MedLine Citation:
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PMID: 20566773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efflux pump inhibitor phenyl-arginine-beta-naphthylamide (PAbetaN) was paired with iron chelators 2,2'-dipyridyl, acetohydroxamic acid, and EDTA to assess synergistic activities against Pseudomonas aeruginosa growth and biofilm formation. All of the tested iron chelators synergistically inhibited P. aeruginosa growth and biofilm formation with PAbetaN. PAbetaN-EDTA showed the most promising activity against P. aeruginosa growth and biofilm formation. |
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Authors:
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Yang Liu; Liang Yang; Søren Molin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-21 |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 54 ISSN: 1098-6596 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-18 Completed Date: 2010-12-01 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 3960-3 Citation Subset: IM |
Affiliation:
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Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark, 2800 Lyngby, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2,2'-Dipyridyl
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pharmacology Anti-Bacterial Agents / pharmacology* Biofilms / drug effects*, growth & development* Dipeptides / pharmacology Drug Synergism Edetic Acid / pharmacology Hydroxamic Acids / pharmacology Iron Chelating Agents / pharmacology* Pseudomonas aeruginosa / drug effects*, growth & development* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Dipeptides; 0/Hydroxamic Acids; 0/Iron Chelating Agents; 0/phenylalanine arginine beta-naphthylamide; 366-18-7/2,2'-Dipyridyl; 546-88-3/acetohydroxamic acid; 60-00-4/Edetic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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