| Synergistic Effects of Arsenic Trioxide and Silibinin on Apoptosis and Invasion in Human Glioblastoma U87MG Cell Line. | |
| | |
MedLine Citation:
|
PMID: 21969006 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Patients with glioblastoma multiforme (GBM) have poor therapeutic outcomes despite their current therapy. In an attempt to increase the efficacy of therapy for GBM, we studied the efficacy of arsenic trioxide (ATO), a newly introduced treatment for glioma, combined with silibinin, a natural polyphenolic flavonoid, in the GBM cell line, U87MG. The combination therapy synergically inhibited metabolic activity, cell proliferation, and gelatinase A and B activities; it also increased apoptosis. Additionally, it decreased the mRNA level of cathepsin B, uPA, matrix metalloproteinase-2 and 9, membrane type 1-MMP, survivin, BCL2, CA9; it increased mRNA level of caspase-3. Altogether, these results showed that ATO and silibinin in some cases improved and/or complemented the anticancer effects. This study may supply insight into the design of new combination cancer therapies to cells intrinsically less sensitive to routine therapies and suggested a new combination therapy for the highly invasive human glioma treatment. |
| | |
Authors:
|
Majid Zaki Dizaji; Mohsen Malehmir; Ardeshir Ghavamzadeh; Kamran Alimoghaddam; Seyed H Ghaffari |
Related Documents
:
|
21684876 - Growth and mitotic potential of multicelled fibers of cotton (malvaceae). 21798086 - Muscle satellite cell proliferation and association: new insights from myofiber time-la... 21971546 - Gtp depletion synergizes the anti-proliferative activity of chemotherapeutic agents in ... 10226776 - Comparison of the timing of hippocampal and subicular spatial signals: implications for... 16773206 - Ly294002, an inhibitor of pi-3k, enhances heat sensitivity independently of p53 status ... 18656426 - In vitro study of cd133 human stem cells labeled with superparamagnetic iron oxide nano... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-4 |
Journal Detail:
|
Title: Neurochemical research Volume: - ISSN: 1573-6903 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Hematology, Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of willow (Salix sp.) as a woody heavy metal accumulator: field survey and in vivo X-ray ...
Next Document: Induction of Vascular GTP-Cyclohydrolase I and Endogenous Tetrahydrobiopterin Synthesis Protect Agai...