Document Detail


Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection.
MedLine Citation:
PMID:  23532923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Tapasin alleles contribute to the outcome of HCV infection by synergizing with polymorphisms at HLA-B in a population-specific manner. This polymorphism may be relevant for peptide vaccination strategies against HCV infection.
Authors:
Shirin Ashraf; Katja Nitschke; Usama M Warshow; Collin R Brooks; Arthur Y Kim; Georg M Lauer; Theresa J Hydes; Matthew E Cramp; Graeme Alexander; Ann-Margaret Little; Robert Thimme; Christoph Neumann-Haefelin; Salim I Khakoo
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-07-29
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-02     Completed Date:  2014-02-13     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  881-9     Citation Subset:  IM    
Copyright Information:
© 2013 by the American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Antiviral Agents / therapeutic use
Cohort Studies
Female
HLA Antigens / genetics,  physiology*
HLA-B Antigens / genetics,  physiology
Hepacivirus*
Hepatitis C / drug therapy*,  physiopathology*
Humans
Logistic Models
Male
Membrane Transport Proteins / genetics,  physiology*
Middle Aged
Polymorphism, Genetic / genetics
Prognosis
Treatment Outcome
Grant Support
ID/Acronym/Agency:
G1001738//Medical Research Council; R01 DA033541/DA/NIDA NIH HHS; R01 DA033541/DA/NIDA NIH HHS; U19 AI0663445/AI/NIAID NIH HHS; U19 AI066345/AI/NIAID NIH HHS; U19 AI082630/AI/NIAID NIH HHS; U19 AI082630/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/HLA Antigens; 0/HLA-B Antigens; 0/Membrane Transport Proteins; 0/tapasin
Comments/Corrections

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