Document Detail


Synergism of sorbinil and normal diet on reversal of stage-II sugar cataract.
MedLine Citation:
PMID:  3931105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sorbinil, an aldose reductase inhibitor, in combination with diet normalization, arrested stage-II galactose cataract and restored lens transparency. During the reversal process, determination of lens dry weight, dulcitol and myo-inositol content as well as individual fiber cell ultrastructure offered a comprehensive index of lens integrity. In this study, young rats received a 50% galactose diet for 10 days to produce a stage-II sugar cataract. Then they were placed on one of the following diets: 50% galactose and Sorbinil (20 mg/kg); 50% galactose; normal diet, normal diet and Sorbinil (20 mg/kg). From each group, equal numbers were sacrificed at 5, 10 and 20 days. Although differences were obtained after 5 and 10 days, the 20-day reversal period provided the most significant findings. Only the combination of Sorbinil and normal diet restored lens transparency, normalized lens myo-inositol content and dry weight and partially restored fiber cell integrity as evidenced by diminished granulation and increased fiber synthesis. Neither Sorbinil treatment during galactose administration nor normal diet alone were sufficient to protect against further cataractogenesis, thus indicating a synergistic effect of Sorbinil in combination with normal diet.
Authors:
A Beyer-Mears; K Kelly; E Cruz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology     Volume:  31     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  1985  
Date Detail:
Created Date:  1985-10-28     Completed Date:  1985-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  170-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aldehyde Reductase / antagonists & inhibitors*
Animals
Cataract / diet therapy,  drug therapy,  therapy*
Combined Modality Therapy
Galactose
Imidazoles / therapeutic use*
Imidazolidines*
Lens, Crystalline / metabolism,  pathology
Male
Rats
Rats, Inbred Strains
Sugar Alcohol Dehydrogenases / antagonists & inhibitors*
Grant Support
ID/Acronym/Agency:
EY-03226/EY/NEI NIH HHS; EY-03247/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Imidazoles; 0/Imidazolidines; 26566-61-0/Galactose; 68367-52-2/sorbinil; EC 1.1.-/Sugar Alcohol Dehydrogenases; EC 1.1.1.21/Aldehyde Reductase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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