| Synergism of insecticides provides evidence of metabolic mechanisms of resistance in the obliquebanded leafroller Choristoneura rosaceana (Lepidoptera: Tortricidae). | |
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MedLine Citation:
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PMID: 15154513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interactions between six insecticides (indoxacarb, cypermethrin, chlorpyrifos, azinphosmethyl, tebufenozide and chlorfenapyr) and three potential synergists, (piperonyl butoxide (PBO), S,S,S-tributyl phosphorotrithioate (DEF) and diethyl maleate (DEM)) were studied by dietary exposure in a multi-resistant and a susceptible strain of the obliquebanded leafroller, Choristoneura rosaceana (Harris). The synergists did not produce appreciable synergism with most of the insecticides in the susceptible strain. Except for tebufenozide, PBO synergized all the insecticides to varying degrees in the resistant strain. A very high level of synergism by PBO was found with indoxacarb, which reduced the resistance level from 705- to 20-fold when PBO was administered alone and to around 10-fold when used in combination with DEF. DEF also synergized indoxacarb, cypermethrin, chlorpyrifos, azinphosmethyl and tebufenozide in the resistant strain. DEM produced synergism of indoxacarb, chlorpyrifos, azinphos-methyl and chlorfenapyr in the resistant strain. DEM was highly synergistic to cypermethrin, and to some extent to tebufenozide in both the susceptible and resistant strains equally, implying that detoxification by glutathione S-transferases was not a mechanism of resistance for these insecticides. The high level of synergism seen with DEM in the case of cypermethrin may be due to an increase in oxidative stress resulting from the removal of the antioxidant, glutathione. These studies indicate that enhanced detoxification, often mediated by cytochrome P-450 monooxygenases, but with probable esterase and glutathione S-transferase contributions in some cases, is the major mechanism imparting resistance to different insecticides in C. rosaceana. |
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Authors:
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Mushtaq Ahmad; Robert M Hollingworth |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Pest management science Volume: 60 ISSN: 1526-498X ISO Abbreviation: Pest Manag. Sci. Publication Date: 2004 May |
Date Detail:
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Created Date: 2004-05-24 Completed Date: 2004-08-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100898744 Medline TA: Pest Manag Sci Country: United States |
Other Details:
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Languages: eng Pagination: 465-73 Citation Subset: IM |
Affiliation:
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Department of Entomology, Center for Integrated Plant Systems, Michigan State University, East Lansing, MI 48824, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Azinphosmethyl / metabolism, toxicity Chlorpyrifos / metabolism, toxicity Drug Synergism Hydrazines / metabolism, toxicity Insecticide Resistance* Insecticides / metabolism, toxicity* Lepidoptera / drug effects*, metabolism Oxazines / metabolism, toxicity Pyrethrins / metabolism, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Hydrazines; 0/Insecticides; 0/Oxazines; 0/Pyrethrins; 0/chlorfenapyr; 0/indoxacarb; 112410-23-8/tebufenozide; 2921-88-2/Chlorpyrifos; 52315-07-8/cypermethrin; 86-50-0/Azinphosmethyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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