| Synergism between cocaine and atropine at the caudal ventrolateral medulla of cats. | |
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MedLine Citation:
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PMID: 11589517 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously reported that the anticholinergic properties of cocaine may be important in cocaine induced apneusis. We have studied the effects of the cholinergic muscarinic antagonist atropine (ATR) on cocaine induced apneusis at the caudal chemosensitive areas of the ventrolateral medulla oblongata (CVLM). Experiments were performed in urethane anesthetized and tracheotomized cats with the CVLM surgically exposed. Topical application of ATR (44 mM ) to the CVLM produced significant decrements in minute ventilation (V(E)) and mean arterial blood pressure (MABP) (P<0.05) but the effects on tidal volume (V(T)), respiratory frequency (f) and heart rate (HR) were not significant. Administration of cocaine (37 mM) to ATR pretreated animals increased the incidence of cocaine induced respiratory arrest to more than twofold greater than when cocaine was administered in the absence of pretreatment. The ATR pretreated animals that did not experience inspiratory arrest after cocaine were shown to exhibit significant decrements in f and V(E) as a consequence of prolonged inspiratory pauses. The reduction in MABP after cocaine in ATR pretreated animals was also significant. These results suggest that ATR enhances the central respiratory toxicity of cocaine by acting synergistically at CVLM chemosensitive sites. |
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Authors:
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O Dehkordi; G C Dennis; R M Millis; M G Randolph; B Said; C O Trouth |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 69 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-10-08 Completed Date: 2001-10-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 2017-25 Citation Subset: IM |
Affiliation:
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Department of Surgery, Howard University Hospital, Washington, DC 20060, USA. odehkordi@howard.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atropine / pharmacology* Cats Cocaine / pharmacology* Drug Synergism Hemodynamics / drug effects* Medulla Oblongata / drug effects*, physiology Respiration / drug effects* |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine; 51-55-8/Atropine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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