Document Detail

Synergism between cocaine and atropine at the caudal ventrolateral medulla of cats.
MedLine Citation:
PMID:  11589517     Owner:  NLM     Status:  MEDLINE    
We have previously reported that the anticholinergic properties of cocaine may be important in cocaine induced apneusis. We have studied the effects of the cholinergic muscarinic antagonist atropine (ATR) on cocaine induced apneusis at the caudal chemosensitive areas of the ventrolateral medulla oblongata (CVLM). Experiments were performed in urethane anesthetized and tracheotomized cats with the CVLM surgically exposed. Topical application of ATR (44 mM ) to the CVLM produced significant decrements in minute ventilation (V(E)) and mean arterial blood pressure (MABP) (P<0.05) but the effects on tidal volume (V(T)), respiratory frequency (f) and heart rate (HR) were not significant. Administration of cocaine (37 mM) to ATR pretreated animals increased the incidence of cocaine induced respiratory arrest to more than twofold greater than when cocaine was administered in the absence of pretreatment. The ATR pretreated animals that did not experience inspiratory arrest after cocaine were shown to exhibit significant decrements in f and V(E) as a consequence of prolonged inspiratory pauses. The reduction in MABP after cocaine in ATR pretreated animals was also significant. These results suggest that ATR enhances the central respiratory toxicity of cocaine by acting synergistically at CVLM chemosensitive sites.
O Dehkordi; G C Dennis; R M Millis; M G Randolph; B Said; C O Trouth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  69     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-10-08     Completed Date:  2001-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2017-25     Citation Subset:  IM    
Department of Surgery, Howard University Hospital, Washington, DC 20060, USA.
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MeSH Terms
Atropine / pharmacology*
Cocaine / pharmacology*
Drug Synergism
Hemodynamics / drug effects*
Medulla Oblongata / drug effects*,  physiology
Respiration / drug effects*
Reg. No./Substance:
50-36-2/Cocaine; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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